Impaired HPV-specific T-cell response in juvenile-onset recurrent respiratory papillomatosis patients

Impaired HPV-specific T-cell response in juvenile-onset recurrent respiratory papillomatosis patients

Copyright © 2022 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 241(2022) vom: 01. Aug., Seite 109046
1. Verfasser: Xi, Yue (VerfasserIn)
Weitere Verfasser: Wang, Wei, Wang, Hua, Wang, Xiaolin, Zhang, Jie, Zhao, Jing, Wang, Guixiang, Gui, Jingang, Ni, Xin
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2022
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Cytokine HPV Immune imbalance JORRP T-cell response
LEADER 01000naa a22002652 4500
001 NLM341665657
003 DE-627
005 20231226012312.0
007 cr uuu---uuuuu
008 231226s2022 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.clim.2022.109046  |2 doi 
028 5 2 |a pubmed24n1138.xml 
035 |a (DE-627)NLM341665657 
035 |a (NLM)35644521 
035 |a (PII)S1521-6616(22)00127-9 
040 |a DE-627  |b ger  |c DE-627  |e rakwb 
041 |a eng 
100 1 |a Xi, Yue  |e verfasserin  |4 aut 
245 1 0 |a Impaired HPV-specific T-cell response in juvenile-onset recurrent respiratory papillomatosis patients 
264 1 |c 2022 
336 |a Text  |b txt  |2 rdacontent 
337 |a ƒaComputermedien  |b c  |2 rdamedia 
338 |a ƒa Online-Ressource  |b cr  |2 rdacarrier 
500 |a Date Completed 09.08.2022 
500 |a Date Revised 25.08.2022 
500 |a published: Print-Electronic 
500 |a Citation Status MEDLINE 
520 |a Copyright © 2022 Elsevier Inc. All rights reserved. 
520 |a Immunologic dysfunction is one of the most important mechanisms underlying the initiation and development of JORRP. The study aimed to explore whether HPV-specific T-cell response was impaired in JORRP patients. We found JORRP patients had a Th2-biased cytokine profile correlated with disease severity in peripheral system. JORRP patients had an increased memory T cells and a reduced naive T cells in circulation. Upon HPV6/11 antigens stimulation, T cells from JORRP patients exhibited a greater activation profile. Of note, JORRP patients presented with a greater number of IL-10- and IL-4-secreting HPV6/11 antigen responding cells than that of IFN-γ and TNF-α secreting responders. Furthermore, in response to HPV6/11 antigen stimulation, JORRP patients showed a reduced level of cell proliferation, an increased level of apoptosis and higher percentage of the differentiated T cells expressing the replicative senescent cell marker CD57. Impaired HPV-specific T-cell responses could be partly responsible for JORRP development 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a Cytokine 
650 4 |a HPV 
650 4 |a Immune imbalance 
650 4 |a JORRP 
650 4 |a T-cell response 
700 1 |a Wang, Wei  |e verfasserin  |4 aut 
700 1 |a Wang, Hua  |e verfasserin  |4 aut 
700 1 |a Wang, Xiaolin  |e verfasserin  |4 aut 
700 1 |a Zhang, Jie  |e verfasserin  |4 aut 
700 1 |a Zhao, Jing  |e verfasserin  |4 aut 
700 1 |a Wang, Guixiang  |e verfasserin  |4 aut 
700 1 |a Gui, Jingang  |e verfasserin  |4 aut 
700 1 |a Ni, Xin  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Clinical immunology (Orlando, Fla.)  |d 1999  |g 241(2022) vom: 01. Aug., Seite 109046  |w (DE-627)NLM098196855  |x 1521-7035  |7 nnns 
773 1 8 |g volume:241  |g year:2022  |g day:01  |g month:08  |g pages:109046 
856 4 0 |u http://dx.doi.org/10.1016/j.clim.2022.109046  |3 Volltext 
912 |a GBV_USEFLAG_A 
912 |a SYSFLAG_A 
912 |a GBV_NLM 
912 |a GBV_ILN_11 
912 |a GBV_ILN_24 
912 |a GBV_ILN_350 
951 |a AR 
952 |d 241  |j 2022  |b 01  |c 08  |h 109046