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231226s2022 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202203993
|2 doi
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|a pubmed24n1138.xml
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|e rakwb
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|a eng
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| 100 |
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|a Whang, Chang-Hee
|e verfasserin
|4 aut
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| 245 |
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|a Systematic Screening and Therapeutic Evaluation of Glyconanoparticles with Differential Cancer Affinities for Targeted Cancer Therapy
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|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 28.07.2022
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|a Date Revised 28.07.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2022 Wiley-VCH GmbH.
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|a Cancer-targeting ligands used for nanomedicines have been limited mostly to antibodies, peptides, aptamers, and small molecules thus far. Here, a library of glycocalyx-mimicking nanoparticles as a platform to enable screening and identification of cancer-targeting nanomedicines is reported. Specifically, a library of 31 artificial glycopolymers composed of either homogeneous or heterogeneous display of five different sugar moieties (β-glucose, β-galactose, α-mannose, β-N-acetyl glucosamine, and β-N-acetyl galactosamine) is converted to a library of glyconanoparticles (GlyNPs). GlyNPs optimal for targeting CT26, DU145, A549, and PC3 tumors are systematically screened and identified. The cypate-conjugated GlyNP displaying α-mannose and β-N-acetyl glucosamine show selective targeting and potent photothermal therapeutic efficacy against A549 human lung tumors. The docetaxel-contained GlyNP displaying β-glucose, β-galactose, and α-mannose demonstrate targeted chemotherapy against DU145 human prostate tumors. The results presented herein collectively demonstrate that the GlyNP library is a versatile platform enabling the identification of cancer-targeting glyconanoparticles and suggest its potential applicability for targeting various diseased cells beyond cancer
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|a Journal Article
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|a cancer
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|a chemotherapy
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|a glyconanoparticles
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|a glycopolymers
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|a photothermal therapy
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|a Glucose
|2 NLM
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|a IY9XDZ35W2
|2 NLM
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|a Glucosamine
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|a Mannose
|2 NLM
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|a PHA4727WTP
|2 NLM
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|a Galactose
|2 NLM
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|a X2RN3Q8DNE
|2 NLM
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| 700 |
1 |
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|a Hong, Jungwoo
|e verfasserin
|4 aut
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|a Kim, Dohyeon
|e verfasserin
|4 aut
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|a Ryu, Hong
|e verfasserin
|4 aut
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|a Jung, Wonsik
|e verfasserin
|4 aut
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|a Son, Youngju
|e verfasserin
|4 aut
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|a Keum, Hyeongseop
|e verfasserin
|4 aut
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|a Kim, Jinjoo
|e verfasserin
|4 aut
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|a Shin, Hocheol
|e verfasserin
|4 aut
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|a Moon, Eugene
|e verfasserin
|4 aut
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|a Noh, Ilkoo
|e verfasserin
|4 aut
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|a Lee, Hee-Seung
|e verfasserin
|4 aut
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|a Jon, Sangyong
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 34(2022), 30 vom: 01. Juli, Seite e2203993
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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|g volume:34
|g year:2022
|g number:30
|g day:01
|g month:07
|g pages:e2203993
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|u http://dx.doi.org/10.1002/adma.202203993
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