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231226s2022 xx |||||o 00| ||eng c |
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|a 10.1111/vcp.13094
|2 doi
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|a pubmed24n1137.xml
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|a (DE-627)NLM341306657
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|a (NLM)35608195
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Li, Xiantang
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Age- and sex-related changes in body weights and clinical pathology analytes in cynomolgus monkeys (Macaca Fascicularis) of Mauritius origin
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|c 2022
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 14.09.2022
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|a Date Revised 15.10.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2022 The Authors. Veterinary Clinical Pathology published by Wiley Periodicals LLC on behalf of American Society for Veterinary Clinical Pathology.
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|a BACKGROUND: Clinical pathology and body weight information for the cynomolgus monkey in the literature is primarily derived from a small number of animals with limited age ranges, varying geographic origins, and mixed genders
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|a OBJECTIVES: This study aimed to summarize the age- and sex-related changes in clinical pathology analytes and body weights in cynomolgus monkeys of Mauritian origin
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|a METHODS: Pre-study age and body weight data were reviewed in 1819 animals, and pre-study hematologic, coagulation, and serum biochemical analytes were reviewed in 1664 animals
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|a RESULTS: Body weights were statistically higher (P < 0.01) in males than females in all age groups (2-10 years). These measurements became prominent after 4 years of age and peaked at 7 to 8 years of age in both sexes. Sex-related differences were noted in reticulocyte (RETIC) counts, creatinine, cholesterol, and triglyceride concentrations, and alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) activities. Age-related differences were noted in RETIC and lymphocyte counts, creatinine, triglyceride, phosphorus, and globulin concentrations, and ALP and GGT activities. The youngest (2 to <3 year) age group had the fewest number of clinical pathologic analyte differences including ALP and GGT activity differences which occurred in all age groups from 2 to 10 years; they also had age-related lower globulin concentrations. There were no age- or sex-related differences in coagulation measurands
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|a CONCLUSIONS: Sexual dimorphism in body weight was apparent for all ages from 2 to 10 years of age. The only difference in clinical pathology analytes unique to the 2 to <3 years of age group were age-related lower globulin levels
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|a Journal Article
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|a Mauritius
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|a body weight
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| 650 |
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|a coagulation
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| 650 |
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4 |
|a cynomolgus monkey
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| 650 |
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4 |
|a hematology
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| 650 |
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4 |
|a serum biochemistry
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| 650 |
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|a Globulins
|2 NLM
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| 650 |
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|a Triglycerides
|2 NLM
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| 650 |
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|a Creatinine
|2 NLM
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| 650 |
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7 |
|a AYI8EX34EU
|2 NLM
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| 700 |
1 |
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|a Li, Dingzhou
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Biddle, Kathleen E
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Portugal, Susan S
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Mark R
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Santos, Rosemary
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Burkhardt, John E
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Khan, Nasir K
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Veterinary clinical pathology
|d 1975
|g 51(2022), 3 vom: 08. Sept., Seite 356-375
|w (DE-627)NLM098159984
|x 1939-165X
|7 nnns
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| 773 |
1 |
8 |
|g volume:51
|g year:2022
|g number:3
|g day:08
|g month:09
|g pages:356-375
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| 856 |
4 |
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|u http://dx.doi.org/10.1111/vcp.13094
|3 Volltext
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