Imbalance of circulating innate lymphoid cell subpopulations in patients with chronic kidney disease

Imbalance of circulating innate lymphoid cell subpopulations in patients with chronic kidney disease

Copyright © 2022 Elsevier Inc. All rights reserved.

Détails bibliographiques
Publié dans:Clinical immunology (Orlando, Fla.). - 1999. - 239(2022) vom: 10. Juni, Seite 109029
Auteur principal: Wang, Ruifeng (Auteur)
Autres auteurs: Zhang, Jingjing, Li, Dandan, Liu, Guiling, Fu, Yuqin, Li, Qing, Zhang, Lei, Qian, Long, Hao, Li, Wang, Yiping, Harris, David C H, Wang, Deguang, Cao, Qi
Format: Article en ligne
Langue:English
Publié: 2022
Accès à la collection:Clinical immunology (Orlando, Fla.)
Sujets:Journal Article Research Support, Non-U.S. Gov't Chronic kidney disease Diabetic nephropathy Innate immunity Innate lymphoid cells Lupus nephritis
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520 |a Innate lymphoid cells (ILCs) are a newly identified heterogeneous family of innate immune cells. We conducted this study to investigate the frequency of circulating ILC subsets in various chronic kidney diseases (CKD). In DN, the proportion of total ILCs and certain ILC subgroups increased significantly. Positive correlations between proportion of total ILCs, ILC1s and body mass index, glycated hemoglobin were observed in DN. In LN, a significantly increased proportion of ILC1s was found in parallel with a reduced proportion of ILC2s. The proportions of total ILCs and ILC1s were correlated with WBC count and the level of C3. In all enrolled patients, the proportion of total ILCs and ILC1s was significantly correlated with the levels of ACR and GFR. In the present study, the proportion of circulating ILC subsets increased significantly in various types of CKD and correlated with clinico-pathological features, which suggests a possible role for ILCs in CKD 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a Chronic kidney disease 
650 4 |a Diabetic nephropathy 
650 4 |a Innate immunity 
650 4 |a Innate lymphoid cells 
650 4 |a Lupus nephritis 
700 1 |a Zhang, Jingjing  |e verfasserin  |4 aut 
700 1 |a Li, Dandan  |e verfasserin  |4 aut 
700 1 |a Liu, Guiling  |e verfasserin  |4 aut 
700 1 |a Fu, Yuqin  |e verfasserin  |4 aut 
700 1 |a Li, Qing  |e verfasserin  |4 aut 
700 1 |a Zhang, Lei  |e verfasserin  |4 aut 
700 1 |a Qian, Long  |e verfasserin  |4 aut 
700 1 |a Hao, Li  |e verfasserin  |4 aut 
700 1 |a Wang, Yiping  |e verfasserin  |4 aut 
700 1 |a Harris, David C H  |e verfasserin  |4 aut 
700 1 |a Wang, Deguang  |e verfasserin  |4 aut 
700 1 |a Cao, Qi  |e verfasserin  |4 aut 
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