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231226s2022 xx |||||o 00| ||eng c |
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|a 10.1111/nph.18211
|2 doi
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|a pubmed24n1135.xml
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|a (DE-627)NLM340529547
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|a (NLM)35524456
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Goodman, Heather L
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Extracellular ATP targets Arabidopsis RIBONUCLEASE 1 to suppress mycotoxin stress-induced cell death
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|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 15.07.2022
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|a Date Revised 15.10.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2022 The Authors. New Phytologist © 2022 New Phytologist Foundation.
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|a Extracellular ATP is a purinergic signal with important functions in regulating plant growth and stress-adaptive responses, including programmed cell death. While signalling events proximate to receptor activation at the plasma membrane have been characterised, downstream protein targets and the mechanism of cell death activation/regulation are unknown. We designed a proteomic screen to identify ATP-responsive proteins in Arabidopsis cell cultures exposed to mycotoxin stress via fumonisin B1 (FB1) application. Arabidopsis RIBONUCLEASE 1 (RNS1) was identified by the screen, and transgenic plants overexpressing native RNS1 showed greater susceptibility to FB1, while a gene knockout rns1 mutant and antisense RNS1 transgenic plants were resistant to FB1-induced cell death. Native RNS1 complemented rns1 mutants and restored the cell death response to FB1, while a catalytically inactive version of the ribonuclease could not. The FB1 resistance of salicylic acid (SA)-depleted nahG-expressing plants was abolished by transformation with native RNS1, but not the catalytically dead version. The mechanism of FB1-induced cell death is activation of RNS1-dependent RNA cleavage, which is blocked by ATP via RNS1 suppression, or enhanced by SA through induction of RNS1 expression. Our study reveals RNS1 as a previously unknown convergence point of ATP and SA signalling in the regulation of stress-induced cell death
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Arabidopsis
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|a RNS1
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|a S-like ribonuclease
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|a extracellular ATP
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|a fumonisin B1
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|a programmed cell death
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|a salicylic acid
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|a Arabidopsis Proteins
|2 NLM
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| 650 |
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|a Mycotoxins
|2 NLM
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| 650 |
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|a Adenosine Triphosphate
|2 NLM
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| 650 |
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|a 8L70Q75FXE
|2 NLM
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| 650 |
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|a RNS1 protein, Arabidopsis
|2 NLM
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| 650 |
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|a EC 3.1.-
|2 NLM
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| 650 |
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|a Ribonucleases
|2 NLM
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| 650 |
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|a EC 3.1.-
|2 NLM
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| 650 |
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|a Salicylic Acid
|2 NLM
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| 650 |
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|a O414PZ4LPZ
|2 NLM
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| 700 |
1 |
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|a Kroon, Johan T M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tomé, Daniel F A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hamilton, John M U
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Alqarni, Ali O
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chivasa, Stephen
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t The New phytologist
|d 1979
|g 235(2022), 4 vom: 01. Aug., Seite 1531-1542
|w (DE-627)NLM09818248X
|x 1469-8137
|7 nnns
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| 773 |
1 |
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|g volume:235
|g year:2022
|g number:4
|g day:01
|g month:08
|g pages:1531-1542
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|u http://dx.doi.org/10.1111/nph.18211
|3 Volltext
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|d 235
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