Simultaneous One-Pot Interpenetrating Network Formation to Expand 3D Processing Capabilities

© 2022 Wiley-VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 34(2022), 28 vom: 29. Juli, Seite e2202261
1. Verfasser: Dhand, Abhishek P (VerfasserIn)
Weitere Verfasser: Davidson, Matthew D, Galarraga, Jonathan H, Qazi, Taimoor H, Locke, Ryan C, Mauck, Robert L, Burdick, Jason A
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2022
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article Digital Light Processing hydrogels interpenetrating polymer networks microparticles photo-crosslinking Biocompatible Materials Hydrogels Polymers Hyaluronic Acid 9004-61-9
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520 |a The incorporation of a secondary network into traditional single-network hydrogels can enhance mechanical properties, such as toughness and loading to failure. These features are important for many applications, including as biomedical materials; however, the processing of interpenetrating polymer network (IPN) hydrogels is often limited by their multistep fabrication procedures. Here, a one-pot scheme for the synthesis of biopolymer IPN hydrogels mediated by the simultaneous crosslinking of two independent networks with light, namely: i) free-radical crosslinking of methacrylate-modified hyaluronic acid (HA) to form the primary network and ii) thiol-ene crosslinking of norbornene-modified HA with thiolated guest-host assemblies of adamantane and β-cyclodextrin to form the secondary network, is reported. The mechanical properties of the IPN hydrogels are tuned by changing the network composition, with high water content (≈94%) hydrogels exhibiting excellent work of fracture, tensile strength, and low hysteresis. As proof-of-concept, the IPN hydrogels are implemented as low-viscosity Digital Light Processing resins to fabricate complex structures that recover shape upon loading, as well as in microfluidic devices to form deformable microparticles. Further, the IPNs are cytocompatible with cell adhesion dependent on the inclusion of adhesive peptides. Overall, the enhanced processing of these IPN hydrogels will expand their utility across applications 
650 4 |a Journal Article 
650 4 |a Digital Light Processing 
650 4 |a hydrogels 
650 4 |a interpenetrating polymer networks 
650 4 |a microparticles 
650 4 |a photo-crosslinking 
650 7 |a Biocompatible Materials  |2 NLM 
650 7 |a Hydrogels  |2 NLM 
650 7 |a Polymers  |2 NLM 
650 7 |a Hyaluronic Acid  |2 NLM 
650 7 |a 9004-61-9  |2 NLM 
700 1 |a Davidson, Matthew D  |e verfasserin  |4 aut 
700 1 |a Galarraga, Jonathan H  |e verfasserin  |4 aut 
700 1 |a Qazi, Taimoor H  |e verfasserin  |4 aut 
700 1 |a Locke, Ryan C  |e verfasserin  |4 aut 
700 1 |a Mauck, Robert L  |e verfasserin  |4 aut 
700 1 |a Burdick, Jason A  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Advanced materials (Deerfield Beach, Fla.)  |d 1998  |g 34(2022), 28 vom: 29. Juli, Seite e2202261  |w (DE-627)NLM098206397  |x 1521-4095  |7 nnns 
773 1 8 |g volume:34  |g year:2022  |g number:28  |g day:29  |g month:07  |g pages:e2202261 
856 4 0 |u http://dx.doi.org/10.1002/adma.202202261  |3 Volltext 
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