Submolecular Ligand Size and Spacing for Cell Adhesion

Bibliographische Detailangaben
Veröffentlicht in:	Advanced materials (Deerfield Beach, Fla.). - 1998. - 34(2022), 27 vom: 27. Juli, Seite e2110340
1. Verfasser:	Kim, Yuri (VerfasserIn)
Weitere Verfasser:	Koo, Thomas Myeongseok, Thangam, Ramar, Kim, Myeong Soo, Jang, Woo Young, Kang, Nayeon, Min, Sunhong, Kim, Seong Yeol, Yang, Letao, Hong, Hyunsik, Jung, Hee Joon, Koh, Eui Kwan, Patel, Kapil D, Lee, Sungkyu, Fu, Hong En, Jeon, Yoo Sang, Park, Bum Chul, Kim, Soo Young, Park, Steve, Lee, Junmin, Gu, Luo, Kim, Dong-Hyun, Kim, Tae-Hyung, Lee, Ki-Bum, Jeong, Woong Kyo, Paulmurugan, Ramasamy, Kim, Young Keun, Kang, Heemin
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2022
Zugriff auf das übergeordnete Werk:	Advanced materials (Deerfield Beach, Fla.)
Schlagworte:	Journal Article cell adhesion ligand size ligand spacing macrophage modulation nanoassemblies submolecular ligands Fibronectins Integrins Ligands mehr... Gold 7440-57-5

Beschreibung
Zusammenfassung:	© 2022 Wiley-VCH GmbH. Cell adhesion occurs when integrin recognizes and binds to Arg-Gly-Asp (RGD) ligands present in fibronectin. In this work, submolecular ligand size and spacing are tuned via template-mediated in situ growth of nanoparticles for dynamic macrophage modulation. To tune liganded gold nanoparticle (GNP) size and spacing from 3 to 20 nm, in situ localized assemblies of GNP arrays on nanomagnetite templates are engineered. 3 nm-spaced ligands stimulate the binding of integrin, which mediates macrophage-adhesion-assisted pro-regenerative polarization as compared to 20 nm-spaced ligands, which can be dynamically anchored to the substrate for stabilizing integrin binding and facilitating dynamic macrophage adhesion. Increasing the ligand size from 7 to 20 nm only slightly promotes macrophage adhesion, not observed with 13 nm-sized ligands. Increasing the ligand spacing from 3 to 17 nm significantly hinders macrophage adhesion that induces inflammatory polarization. Submolecular tuning of ligand spacing can dominantly modulate host macrophages
Beschreibung:	Date Completed 08.07.2022 Date Revised 08.07.2022 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-4095
DOI:	10.1002/adma.202110340