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231226s2022 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202201888
|2 doi
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|a pubmed24n1133.xml
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|a eng
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| 100 |
1 |
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|a Sun, Mengmeng
|e verfasserin
|4 aut
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| 245 |
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|a Magnetic Microswarm and Fluoroscopy-Guided Platform for Biofilm Eradication in Biliary Stents
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|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
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|a Date Completed 26.08.2022
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|a Date Revised 26.08.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2022 Wiley-VCH GmbH.
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|a Biofilm eradication from medical implants is of fundamental importance, and the treatment of biofilm-associated pathogen infections on inaccessible biliary stents remains challenging. Magnetically driven microrobots with controlled motility, accessibility to the tiny lumen, and swarm enhancement effects can physically disrupt the deleterious biostructures while not developing drug resistance. Magnetic urchin-like capsule robots (MUCRs) loaded with magnetic liquid metal droplets (MLMDs, antibacterial agents) are designed using natural sunflower pollen, and the therapeutic effect of swarming MUCRMLMDs is explored for eradicating complex mixtures of bacterial biofilm within biliary stents collected from patients. The external magnetic field triggers the emergence of the microswarm and induces MLMDs to transform their shape into spheroids and rods with sharp edges. The inherent natural microspikes of MUCRs and the obtained sharp edges of MLMDs actively rupture the dense biological matrix and multiple species of embedded bacterial cells by exerting mechanical force, finally achieving synergistic biofilm eradication. The microswarm is precisely and rapidly deployed into the biliary stent via endoscopy in 10 min. Notably, fluoroscopy imaging is used to track and navigate the locomotion of microswarm in biliary stents in real-time. The microswarm has great potential for treating bacterial biofilm infections associated with medical implants
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|a Journal Article
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|a biofilm eradication
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|a liquid metal
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|a magnetic actuation
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|a microrobotic swarm
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|a urchin-like microrobots
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|a Anti-Bacterial Agents
|2 NLM
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1 |
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|a Chan, Kai Fung
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Zifeng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Lu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Qinglong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Shihao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chan, Shannon Melissa
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chiu, Philip Wai Yan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sung, Joseph Jao Yiu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Li
|e verfasserin
|4 aut
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| 773 |
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|t Advanced materials (Deerfield Beach, Fla.)
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|g 34(2022), 34 vom: 26. Aug., Seite e2201888
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|g year:2022
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|u http://dx.doi.org/10.1002/adma.202201888
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