|
|
|
|
| LEADER |
01000naa a22002652 4500 |
| 001 |
NLM339997060 |
| 003 |
DE-627 |
| 005 |
20231226004141.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231226s2022 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1021/acs.langmuir.2c00067
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n1133.xml
|
| 035 |
|
|
|a (DE-627)NLM339997060
|
| 035 |
|
|
|a (NLM)35470663
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Li, Jinling
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a NIR-II-Responsive CeO2-xHA Nanotheranostics for Photoacoustic Imaging-Guided Sonodynamic-Enhanced Synergistic Phototherapy
|
| 264 |
|
1 |
|c 2022
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 11.05.2022
|
| 500 |
|
|
|a Date Revised 05.07.2022
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a The therapeutic effect of photothermal therapy (PTT) and photodynamic therapy (PDT) is severely limited because of the shallow tissue penetration depth of the first near-infrared (NIR-I) light. Multifunctional nanotheranostics irradiated by the second near-infrared (NIR-II) light have received wide interest with respect to deeper tissue penetration, and sonodynamic therapy (SDT) synergistic phototherapy can achieve the complete elimination of tumors. Herein, we successfully constructed a single NIR-II light-induced nanotheranostic using cerium oxide (CeO2-x) with abundant oxygen vacancies for photoacoustic imaging-guided SDT-enhanced phototherapy for the first time. CeO2-x with surface crystalline disorder showed extensive NIR-II region absorption and an outstanding photothermal conversion ability. In addition, the CeO2-x layer with numerous oxygen defects can promote the separation of holes and electrons by ultrasound irradiation, which can remarkably enhance the efficacy of phototherapy to achieve high-efficiency tumor ablation. CeO2-x was surface modified with hyaluronic acid (HA) to prepare CeO2-xHA to allow active tumor targeting efficiency. Both cell and animal experiments confirmed that all-in-one CeO2-x@HA exhibited a high therapeutic efficacy of SDT-enhanced PDT/PTT under 1064 nm laser irradiation, which achieved complete tumor eradication without systemic toxicity. This study significantly broadened the application of NIR-II-responsive CeO2-x for photoacoustic imaging-mediated SDT-enhanced phototherapy to the highly efficient and precise elimination of tumors
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
7 |
|a Hyaluronic Acid
|2 NLM
|
| 650 |
|
7 |
|a 9004-61-9
|2 NLM
|
| 650 |
|
7 |
|a Oxygen
|2 NLM
|
| 650 |
|
7 |
|a S88TT14065
|2 NLM
|
| 700 |
1 |
|
|a Peng, Hui-Ling
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Wen, Changchun
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Xu, Peijing
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Shen, Xing-Can
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Gao, Cunji
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 38(2022), 18 vom: 10. Mai, Seite 5502-5514
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
|
| 773 |
1 |
8 |
|g volume:38
|g year:2022
|g number:18
|g day:10
|g month:05
|g pages:5502-5514
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1021/acs.langmuir.2c00067
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_22
|
| 912 |
|
|
|a GBV_ILN_350
|
| 912 |
|
|
|a GBV_ILN_721
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 38
|j 2022
|e 18
|b 10
|c 05
|h 5502-5514
|