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|a 10.1111/vcp.13124
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|a eng
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|a Henker, Luan C
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Duodenal leiomyosarcoma in a cat
|b Cytologic, pathologic, and immunohistochemical findings
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| 264 |
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|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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| 500 |
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|a Date Completed 02.12.2022
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|a Date Revised 02.12.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a © 2022 American Society for Veterinary Clinical Pathology.
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|a A 7-year-old mixed-breed neutered male cat was presented with a history of chronic vomiting with increased frequency in the last month, progressing to depression and profuse projectile vomiting. Abdominal ultrasonography revealed an area of marked segmental duodenal thickening associated with a nodule, and euthanasia was performed due to a poor prognosis. Grossly, at the postmortem examination, the wall of a duodenal segment was severely expanded by a nodule measuring 5.0 cm in diameter, resulting in marked luminal narrowing and obstruction. Smears were made by scraping the cut surface of the tumor during the postmortem examination. The smears were highly cellular and contained mesenchymal cells arranged individually or in large non-cohesive aggregates. Cells varied in morphology from spindle to round to stellate-shaped with marked anisocytosis and anisokaryosis. Numerous bi- and multinucleated neoplastic cells were observed. Histologic examination revealed a densely cellular neoplastic proliferation of mesenchymal cells that effaced the duodenal submucosa, muscularis externa, and serosa layers. Most cells were spindle-shaped; however, some tumor areas had numerous round cells and bi- and multinucleated neoplastic cells. Spindle cells showed variable cytoplasmic immunoreactivity for vimentin, smooth muscle actin, and desmin. Round, bi-, and multinucleated giant cells only had marked multifocal cytoplasmic immunoreactivity for vimentin. Neoplastic cells did not have immunoreactivity for cytokeratin, GFAP, S100, and CD117. A final diagnosis of duodenal leiomyosarcoma was made. This article reports the pathologic, cytologic, and immunohistochemical findings of this case and discusses the main differential diagnoses in cases of intestinal sarcomas in domestic animals
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| 650 |
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|a Case Reports
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|a Journal Article
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| 650 |
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|a cytology
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| 650 |
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|a differential diagnosis
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| 650 |
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|a feline
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| 650 |
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|a non-lymphogenic intestinal mesenchymal tumors
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| 650 |
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|a nonangiogenic
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| 650 |
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|a Vimentin
|2 NLM
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| 700 |
1 |
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|a Dal Pont, Tainah P
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dos Santos, Igor R
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bandinelli, Marcele B
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zardo, Izadora L
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rodrigues, Rochana
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Pavarini, Saulo P
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Veterinary clinical pathology
|d 1975
|g 51(2022), 4 vom: 01. Dez., Seite 507-510
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|g volume:51
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