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231226s2022 xx |||||o 00| ||eng c |
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|a 10.1155/2022/7251460
|2 doi
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|a pubmed25n1132.xml
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Ilbay, Gul
|e verfasserin
|4 aut
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| 245 |
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|a Neonatal Tactile Stimulation Downregulates Dendritic Spines in Layer V Pyramidal Neurons of the WAG/Rij Rat Somatosensory Cortex
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|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 26.04.2022
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|a Date Revised 26.08.2024
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|a published: Electronic-eCollection
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|a Citation Status MEDLINE
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|a Copyright © 2022 Gul Ilbay et al.
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|a Objective: The aim of our study is to examine the effects of neonatal tactile stimulations on the brain structures that previously defined as the focus of epilepsy in the Wistar-Albino-Glaxo from Rijswijk (WAG/Rij) rat brain with genetic absence epilepsy
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|a Methods: In the present research, morphology and density of dendritic spines were analyzed in layer V pyramidal neurons of the somatosensory cortex (SoCx) of WAG/Rij rats (nonstimulated control, tactile-stimulated, and maternal separated rats) and healthy Wistar (nonepileptic) rats. To achieve this, a Golgi-Cox method was used
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|a Results: Dendritic spine number in layer V of the SoCx has been detected significantly higher in adult WAG/Rij rats at postnatal day 150 in comparison to nonepileptic adult control Wistar rats (p < 0.001). Moreover, quantitative analyses of dendrite structure in adult WAG/Rij rats showed a decrease in dendrite spine density of pyramidal neurons of SoCx which occurred in early neonatal exposure to maternal separation (MS) and tactile stimulation (TS) (p < 0.001)
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|a Conclusions: Our findings provide the first evidence that tactile stimulations during the early postnatal period have a long-term impact on dendrite structure in WAG/Rij rat's brain and demonstrate that neonatal tactile stimulation can regulate dendritic spines in layer V in pyramidal neurons of SoCx in epileptic brains
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|a Journal Article
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1 |
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|a Balıkcı, Aymen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Köktürk, Sibel
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yılmaz, Melda Yardımoglu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ates, Nurbay
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Baydemır, Canan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Balcı, Sibel
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Neural plasticity
|d 1998
|g 2022(2022) vom: 15., Seite 7251460
|w (DE-627)NLM098558390
|x 1687-5443
|7 nnas
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| 773 |
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|g volume:2022
|g year:2022
|g day:15
|g pages:7251460
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|u http://dx.doi.org/10.1155/2022/7251460
|3 Volltext
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