Ultrasensitive Mid-Infrared Biosensing in Aqueous Solutions with Graphene Plasmons
© 2022 Wiley-VCH GmbH.
| Veröffentlicht in: | Advanced materials (Deerfield Beach, Fla.). - 1998. - 34(2022), 27 vom: 05. Juli, Seite e2110525 |
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| Weitere Verfasser: | , , , , , , , , , |
| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2022
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| Zugriff auf das übergeordnete Werk: | Advanced materials (Deerfield Beach, Fla.) |
| Schlagworte: | Journal Article aqueous solutions biosensing graphene plasmons surface-enhanced infrared spectroscopy Proteins Water 059QF0KO0R Graphite 7782-42-5 |
| Zusammenfassung: | © 2022 Wiley-VCH GmbH. Identifying nanoscale biomolecules in aqueous solutions by Fourier transform infrared spectroscopy (FTIR) provides an in situ and noninvasive method for exploring the structure, reactions, and transport of biologically active molecules. However, this remains a challenge due to the strong and broad IR absorption of water which overwhelms the respective vibrational fingerprints of the biomolecules. In this work, a tunable IR transparent microfluidic system with graphene plasmons is exploited to identify ≈2 nm-thick proteins in physiological conditions. The acquired in situ tunability makes it possible to eliminate the IR absorption of water outside the graphene plasmonic hotspots by background subtraction. Most importantly, the ultrahigh confinement of graphene plasmons (confined to ≈15 nm) permits the implementation of nanoscale sensitivity. Then, the deuterium effects on monolayer proteins are characterized within an aqueous solution. The tunable graphene-plasmon-enhanced FTIR technology provides a novel platform for studying biological processes in an aqueous solution at the nanoscale |
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| Beschreibung: | Date Completed 08.07.2022 Date Revised 08.07.2022 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1521-4095 |
| DOI: | 10.1002/adma.202110525 |