MoIug4 is a novel secreted effector promoting rice blast by counteracting host OsAHL1-regulated ethylene gene transcription

Bibliographische Detailangaben
Veröffentlicht in:	The New phytologist. - 1979. - 235(2022), 3 vom: 06. Aug., Seite 1163-1178
1. Verfasser:	Liu, Xinyu (VerfasserIn)
Weitere Verfasser:	Gao, Yixin, Guo, Ziqian, Wang, Nian, Wegner, Alex, Wang, Jintao, Zou, Xi, Hu, Jiexiong, Liu, Muxing, Zhang, Haifeng, Zheng, Xiaobo, Wang, Ping, Schaffrath, Ulrich, Zhang, Zhengguang
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2022
Zugriff auf das übergeordnete Werk:	The New phytologist
Schlagworte:	Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural Magnaporthe oryzae effector ethylene signaling plant immunity transcription reprogramming Ethylenes Transcription Factors

Beschreibung
Zusammenfassung:	© 2022 The Authors. New Phytologist © 2022 New Phytologist Foundation. Magnaporthe oryzae secretes several effectors that modulate and hijack rice processes to colonize host cells, but the underlying mechanisms remain unclear. We report on a novel cytoplasmic effector MoIug4 that targets the rice ethylene pathway as a transcription repressor to subvert host immunity. We found that MoIug4 binds to the promoter of the host OsEIN2 gene that encodes a central signal transducer in the ethylene-signaling pathway. We also identified a MoIug4 interacting protein, OsAHL1, which acts as an AT-hook motif-containing protein binding to the A/T-rich promoter regions. Our knockout and overexpression studies showed that OsAHL1 positively regulates plant immunity in response to M. oryzae infection. OsAHL1 exhibits transcriptional regulatory activities by binding the OsEIN2 promoter region, similar to MoIug4. Intriguingly, we found that MoIug4 exhibits a higher binding affinity than OsAHL1 to the OsEIN2 promoter, suggesting differential regulatory specificities. These results revealed a counter-defense strategy by which the pathogen effector suppresses the activation of host defense genes by interfering with host transcription activator functions
Beschreibung:	Date Completed 01.07.2022 Date Revised 12.06.2024 published: Print-Electronic Citation Status MEDLINE
ISSN:	1469-8137
DOI:	10.1111/nph.18169