Protective HLA alleles against severe COVID-19 HLA-A*68 as an ancestral protection allele in Tapachula-Chiapas, Mexico

Protective HLA alleles against severe COVID-19 : HLA-A*68 as an ancestral protection allele in Tapachula-Chiapas, Mexico

Copyright © 2022 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 238(2022) vom: 15. Mai, Seite 108990
1. Verfasser: Hernández-Doño, Susana (VerfasserIn)
Weitere Verfasser: Sánchez-González, Roberto Alejandro, Trujillo-Vizuet, Ma Guadalupe, Zamudio-Castellanos, Fabiola Yeseline, García-Silva, Rafael, Bulos-Rodríguez, Pedro, Vazquez-Guzmán, Carlos A, Cárdenas-Ramos, Ximena, de León Rodríguez, Diana, Elías, Fabiola, Domínguez-Arrevillaga, Sergio, Pérez-Tirado, José Manuel, Vera-Lastra, Olga Lidia, Granados, Julio, Sepúlveda-Delgado, Jesús
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2022
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article COVID-19 HLA MHC México SARS-CoV-2 HLA-A Antigens HLA-A*68 antigen HLA-DRB1 Chains
Beschreibung
Zusammenfassung:Copyright © 2022 Elsevier Inc. All rights reserved.
HLA is a polymorphic antigen presenter which has provided valuable information on the susceptibility of populations to viruses. Therefore, the study of HLA can reveal specific susceptibility or resistance alleles to severe COVID-19 in an ethnically dependent manner. This pilot study investigated HLA alleles associated with COVID-19 severity in Tapachula, Chiapas, Mexico. A total of 146 Mexican Mestizos were typed for HLA class I and II using PCR-SSP. The patients were classified according to the outcome (death or improvement) and the infection's severity (mild or severe). In addition, a group of exposed uninfected individuals was included. HLA-A*68 was found to be a protective allele against the severe infection and fatal outcome; pC = 0.03, OR = 0.4, 95% CI =0.20-0.86, and pC =0.009, OR = 0.3, 95% CI =0.13-0.71 respectively. HLA-DRB1*03 also appears to be a protective factor against fatal outcome pC = 0.009, OR = 0.1, 95%IC = 0.01-0.66; however, the low frequency of this allele in the studied population limits the statistical power. The severity and fatal outcome of COVID-19 patients in Tapachula, Chiapas depend more on the lack of resistance than susceptibility HLA alleles
Beschreibung:Date Completed 17.05.2022
Date Revised 21.12.2022
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2022.108990