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231226s2022 xx |||||o 00| ||eng c |
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|a 10.1093/jxb/erac135
|2 doi
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|a pubmed24n1130.xml
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|a (DE-627)NLM339241756
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|a (NLM)35394500
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Agaoua, Aimeric
|e verfasserin
|4 aut
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|a A single substitution in Vacuolar protein sorting 4 is responsible for resistance to Watermelon mosaic virus in melon
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|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 28.06.2022
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|a Date Revised 03.08.2022
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|a published: Print
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|a Citation Status MEDLINE
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|a © The Author(s) 2022. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissionsoup.com.
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|a In plants, introgression of genetic resistance is a proven strategy for developing new resistant lines. While host proteins involved in genome replication and cell to cell movement are widely studied, other cell mechanisms responsible for virus infection remain under investigated. Endosomal sorting complexes required for transport (ESCRT) play a key role in membrane trafficking in plants and are involved in the replication of several plant RNA viruses. In this work, we describe the role of the ESCRT protein CmVPS4 as a new susceptibility factor to the Potyvirus Watermelon mosaic virus (WMV) in melon. Using a worldwide collection of melons, we identified three different alleles carrying non-synonymous substitutions in CmVps4. Two of these alleles were shown to be associated with WMV resistance. Using a complementation approach, we demonstrated that resistance is due to a single non-synonymous substitution in the allele CmVps4P30R. This work opens up new avenues of research on a new family of host factors required for virus infection and new targets for resistance
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Cucumis melo
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4 |
|a Potyvirus
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|a ESCRT
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|a VPS4
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|a WMV
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|a plant
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| 650 |
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|a resistance
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| 650 |
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|a Endosomal Sorting Complexes Required for Transport
|2 NLM
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| 700 |
1 |
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|a Rittener, Vincent
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Troadec, Christelle
|e verfasserin
|4 aut
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| 700 |
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|a Desbiez, Cécile
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bendahmane, Abdelhafid
|e verfasserin
|4 aut
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| 700 |
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|a Moquet, Frédéric
|e verfasserin
|4 aut
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| 700 |
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|a Dogimont, Catherine
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Journal of experimental botany
|d 1985
|g 73(2022), 12 vom: 24. Juni, Seite 4008-4021
|w (DE-627)NLM098182706
|x 1460-2431
|7 nnns
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| 773 |
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|g volume:73
|g year:2022
|g number:12
|g day:24
|g month:06
|g pages:4008-4021
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|u http://dx.doi.org/10.1093/jxb/erac135
|3 Volltext
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