Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19

Copyright © 2022. Published by Elsevier Inc.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 237(2022) vom: 12. Apr., Seite 108991
1. Verfasser: Kaneko, Naoki (VerfasserIn)
Weitere Verfasser: Boucau, Julie, Kuo, Hsiao-Hsuan, Perugino, Cory, Mahajan, Vinay S, Farmer, Jocelyn R, Liu, Hang, Diefenbach, Thomas J, Piechocka-Trocha, Alicja, Lefteri, Kristina, Waring, Michael T, Premo, Katherine R, Walker, Bruce D, Li, Jonathan Z, Gaiha, Gaurav, Yu, Xu G, Lichterfeld, Mathias, Padera, Robert F Jr, Pillai, Shiv
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2022
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't CD8+ T cells COVID-19 Cytotoxic CD4+ T cells
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100 1 |a Kaneko, Naoki  |e verfasserin  |4 aut 
245 1 0 |a Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19 
264 1 |c 2022 
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500 |a Date Completed 18.04.2022 
500 |a Date Revised 14.09.2024 
500 |a published: Print-Electronic 
500 |a UpdateOf: medRxiv. 2021 Mar 26:2021.03.23.21253885. doi: 10.1101/2021.03.23.21253885. - PMID 33791730 
500 |a Citation Status MEDLINE 
520 |a Copyright © 2022. Published by Elsevier Inc. 
520 |a Many studies have been performed in severe COVID-19 on immune cells in the circulation and on cells obtained by bronchoalveolar lavage. Most studies have tended to provide relative information rather than a quantitative view, and it is a combination of approaches by various groups that is helping the field build a picture of the mechanisms that drive severe lung disease. Approaches employed to date have not revealed information on lung parenchymal T cell subsets in severe COVID-19. Therefore, we sought to examine early and late T cell subset alterations in the lungs and draining lymph nodes in severe COVID-19 using a rapid autopsy protocol and quantitative imaging approaches. Here, we have established that cytotoxic CD4+ T cells (CD4 + CTLs) increase in the lungs, draining lymph nodes and blood as COVID-19 progresses. CD4 + CTLs are prominently expanded in the lung parenchyma in severe COVID-19. In contrast CD8+ T cells are not prominent, exhibit increased PD-1 expression, and no obvious increase is seen in the number of Granzyme B+ CD8+ T cells in the lung parenchyma in severe COVID-19. Based on quantitative evidence for re-activation in the lung milieu, CD4 + CTLs may be as likely to drive viral clearance as CD8+ T cells and may also be contributors to lung inflammation and eventually to fibrosis in severe COVID-19 
650 4 |a Journal Article 
650 4 |a Research Support, N.I.H., Extramural 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a CD8+ T cells 
650 4 |a COVID-19 
650 4 |a Cytotoxic CD4+ T cells 
700 1 |a Boucau, Julie  |e verfasserin  |4 aut 
700 1 |a Kuo, Hsiao-Hsuan  |e verfasserin  |4 aut 
700 1 |a Perugino, Cory  |e verfasserin  |4 aut 
700 1 |a Mahajan, Vinay S  |e verfasserin  |4 aut 
700 1 |a Farmer, Jocelyn R  |e verfasserin  |4 aut 
700 1 |a Liu, Hang  |e verfasserin  |4 aut 
700 1 |a Diefenbach, Thomas J  |e verfasserin  |4 aut 
700 1 |a Piechocka-Trocha, Alicja  |e verfasserin  |4 aut 
700 1 |a Lefteri, Kristina  |e verfasserin  |4 aut 
700 1 |a Waring, Michael T  |e verfasserin  |4 aut 
700 1 |a Premo, Katherine R  |e verfasserin  |4 aut 
700 1 |a Walker, Bruce D  |e verfasserin  |4 aut 
700 1 |a Li, Jonathan Z  |e verfasserin  |4 aut 
700 1 |a Gaiha, Gaurav  |e verfasserin  |4 aut 
700 1 |a Yu, Xu G  |e verfasserin  |4 aut 
700 1 |a Lichterfeld, Mathias  |e verfasserin  |4 aut 
700 1 |a Padera, Robert F  |c Jr  |e verfasserin  |4 aut 
700 1 |a Pillai, Shiv  |e verfasserin  |4 aut 
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