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231226s2022 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.2c00101
|2 doi
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|a pubmed25n1129.xml
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|a eng
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| 100 |
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|a Du, Enming
|e verfasserin
|4 aut
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|a Enhancing the Cellular Uptake of Macromolecules via Enzyme-Instructed Self-Assembly
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|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 13.04.2022
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|a Date Revised 04.05.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Poor solubility, low cellular uptake, and poor cell selectivity are the main obstacles hampering the therapeutic potential and clinic application of macromolecules. To overcome these limitations, here we propose a chemical modification strategy of macromolecules based on enzyme-instructed self-assembly (EISA). By using protoporphyrin IX (PpIX) and its metal complex Zn-PpIX as the modification objects, we demonstrated that the integration of enzymatic transformation and molecular self-assembly of macromolecules successfully improved the solubility of macromolecules, enhancing their intracellular uptake selectively against cancer cells. The proposed strategy is potentially applicable as a general tool for the development of macromolecule-based nanomedicine
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Antineoplastic Agents
|2 NLM
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| 700 |
1 |
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|a Tang, Yunlan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Qizheng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Song, Zongming
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tao, Ye
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Ye
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1985
|g 38(2022), 14 vom: 12. Apr., Seite 4364-4370
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnas
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| 773 |
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|g volume:38
|g year:2022
|g number:14
|g day:12
|g month:04
|g pages:4364-4370
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|u http://dx.doi.org/10.1021/acs.langmuir.2c00101
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