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231226s2022 xx |||||o 00| ||eng c |
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|a 10.1021/acs.chemmater.1c04342
|2 doi
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|a pubmed24n1129.xml
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|a (DE-627)NLM338904336
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|a DE-627
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|a eng
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|a Mousa, Abdelrazek H
|e verfasserin
|4 aut
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| 245 |
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|a Method Matters
|b Exploring Alkoxysulfonate-Functionalized Poly(3,4-ethylenedioxythiophene) and Its Unintentional Self-Aggregating Copolymer toward Injectable Bioelectronics
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|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Revised 02.04.2022
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|a published: Print-Electronic
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|a Citation Status PubMed-not-MEDLINE
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|a © 2022 The Authors. Published by American Chemical Society.
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|a Injectable bioelectronics could become an alternative or a complement to traditional drug treatments. To this end, a new self-doped p-type conducting PEDOT-S copolymer (A5) was synthesized. This copolymer formed highly water-dispersed nanoparticles and aggregated into a mixed ion-electron conducting hydrogel when injected into a tissue model. First, we synthetically repeated most of the published methods for PEDOT-S at the lab scale. Surprisingly, analysis using high-resolution matrix-assisted laser desorption ionization-mass spectroscopy showed that almost all the methods generated PEDOT-S derivatives with the same polymer lengths (i.e., oligomers, seven to eight monomers in average); thus, the polymer length cannot account for the differences in the conductivities reported earlier. The main difference, however, was that some methods generated an unintentional copolymer P(EDOT-S/EDOT-OH) that is more prone to aggregate and display higher conductivities in general than the PEDOT-S homopolymer. Based on this, we synthesized the PEDOT-S derivative A5, that displayed the highest film conductivity (33 S cm-1) among all PEDOT-S derivatives synthesized. Injecting A5 nanoparticles into the agarose gel cast with a physiological buffer generated a stable and highly conductive hydrogel (1-5 S cm-1), where no conductive structures were seen in agarose with the other PEDOT-S derivatives. Furthermore, the ion-treated A5 hydrogel remained stable and maintained initial conductivities for 7 months (the longest period tested) in pure water, and A5 mixed with Fe3O4 nanoparticles generated a magnetoconductive relay device in water. Thus, we have successfully synthesized a water-processable, syringe-injectable, and self-doped PEDOT-S polymer capable of forming a conductive hydrogel in tissue mimics, thereby paving a way for future applications within in vivo electronics
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|a Journal Article
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|a Bliman, David
|e verfasserin
|4 aut
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|a Hiram Betancourt, Lazaro
|e verfasserin
|4 aut
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|a Hellman, Karin
|e verfasserin
|4 aut
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| 700 |
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|a Ekström, Peter
|e verfasserin
|4 aut
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| 700 |
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|a Savvakis, Marios
|e verfasserin
|4 aut
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| 700 |
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|a Strakosas, Xenofon
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Marko-Varga, György
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Berggren, Magnus
|e verfasserin
|4 aut
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| 700 |
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|a Hjort, Martin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ek, Fredrik
|e verfasserin
|4 aut
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| 700 |
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|a Olsson, Roger
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Chemistry of materials : a publication of the American Chemical Society
|d 1998
|g 34(2022), 6 vom: 22. März, Seite 2752-2763
|w (DE-627)NLM098194763
|x 0897-4756
|7 nnns
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| 773 |
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|g volume:34
|g year:2022
|g number:6
|g day:22
|g month:03
|g pages:2752-2763
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|u http://dx.doi.org/10.1021/acs.chemmater.1c04342
|3 Volltext
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