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231226s2022 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2022.108989
|2 doi
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|a pubmed25n1129.xml
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|a (DE-627)NLM33888680X
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|a (NLM)35358679
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|a (PII)S1521-6616(22)00070-5
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Lai, Nannan
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Toll-like receptor 10 expression in B cells is negatively correlated with the progression of primary Sjögren's disease
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|c 2022
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 18.04.2022
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|a Date Revised 31.05.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2022. Published by Elsevier Inc.
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|a Primary Sjögren's Disease (pSjD) is considered a B cell-mediated disease. Toll-like receptor 10 (TLR10) is highly expressed in human B cells, indicating that TLR10 probably plays a vital role in pSjD. We examined TLR10 expression in peripheral B subsets of pSjD patients and analyzed their association with disease activity. We observed that TLR10 expression in total, naïve, memory, and switched memory B cells was significantly increased in low-activity pSjD patients as compared with healthy controls and high-activity patients. TLR10 expression in the above mentioned B subsets (except naïve B) was negatively correlated with serum levels of anti-SSA antibody and BAFF, respectively. Moreover, a higher proportion of high-activity pSjD patients was observed in TLR10 low- than high-expressed patients. Our study concluded that TLR10 expression in CD19+ B and memory B was negatively correlated with pSjD disease activity, suggesting that TLR10 might take part in the progression of pSjD
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4 |
|a Journal Article
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4 |
|a Autoantibodies
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4 |
|a B cells
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| 650 |
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|a B-cell-activating factor of the tumour necrosis factor family
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| 650 |
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4 |
|a Primary Sjögren's disease
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| 650 |
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4 |
|a Toll-like receptor 10
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| 650 |
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7 |
|a Antigens, CD19
|2 NLM
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| 650 |
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|a TLR10 protein, human
|2 NLM
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| 650 |
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7 |
|a Toll-Like Receptor 10
|2 NLM
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| 700 |
1 |
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|a Qian, YiChao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wu, Yilin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jiang, Xi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sun, Honghua
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Luo, Zhaofan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhao, Yanli
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zeng, Changchun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zheng, Xiaoming
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhan, Xiao-Yong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tang, Chun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Qingwen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Huang, Bihui
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 237(2022) vom: 15. Apr., Seite 108989
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnas
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| 773 |
1 |
8 |
|g volume:237
|g year:2022
|g day:15
|g month:04
|g pages:108989
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2022.108989
|3 Volltext
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|a AR
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|h 108989
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