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231226s2022 xx |||||o 00| ||eng c |
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|a 10.1021/acs.organomet.1c00519
|2 doi
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|a pubmed25n1127.xml
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|a eng
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1 |
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|a Schoch, Silvia
|e verfasserin
|4 aut
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| 245 |
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|a Tethering Carbohydrates to the Vinyliminium Ligand of Antiproliferative Organometallic Diiron Complexes
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|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Revised 22.03.2022
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|a published: Print-Electronic
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|a Citation Status PubMed-not-MEDLINE
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|a © 2022 The Authors. Published by American Chemical Society.
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|a Four propargyl O-glycosides derivatized with mannose, glucose, and fructose moieties were synthesized and then incorporated within a diiron structure as part of a vinyliminium ligand. Hence, six glycoconjugated diiron complexes, [2-5]CF3SO3 (see Scheme 1) and the nonglycosylated analogues [6a-b]CF3SO3, were obtained in high yields and unambiguously characterized by elemental analysis, mass spectrometry, and IR and multinuclear NMR spectroscopies. All compounds exhibited a significant stability in DMSO-d 6/D2O solution, with 63-89% of the complexes unaltered after 72 h at 37 °C and also in the cell culture medium. The cytotoxicity of [2-6]CF3SO3, as well as that of previously reported 7 and 8, was assessed on CT26 (mouse colon carcinoma), U87 (human glioblastoma), MCF-7 (human breast adenocarcinoma), and RPE-1 (human normal retina pigmented epithelium) cell lines. In general, the IC50 values correlate with the hydrophobicity of the compounds (measured as octanol-water partition coefficients) and do not show an appreciable level of selectivity against cancer cells with respect to the nontumor ones
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|a Journal Article
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1 |
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|a Iacopini, Dalila
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dalla Pozza, Maria
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Di Pietro, Sebastiano
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Degano, Ilaria
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gasser, Gilles
|e verfasserin
|4 aut
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|a Di Bussolo, Valeria
|e verfasserin
|4 aut
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|a Marchetti, Fabio
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Organometallics
|d 1998
|g 41(2022), 5 vom: 14. März, Seite 514-526
|w (DE-627)NLM098167103
|x 0276-7333
|7 nnas
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| 773 |
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|g volume:41
|g year:2022
|g number:5
|g day:14
|g month:03
|g pages:514-526
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|u http://dx.doi.org/10.1021/acs.organomet.1c00519
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