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231226s2022 xx |||||o 00| ||eng c |
| 024 |
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|a 10.1111/nph.18104
|2 doi
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|a pubmed25n1127.xml
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|a (DE-627)NLM338371923
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|a (NLM)35306666
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Zacharaki, Vasiliki
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Impaired KIN10 function restores developmental defects in the Arabidopsis trehalose 6-phosphate synthase1 (tps1) mutant
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| 264 |
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|c 2022
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 03.06.2022
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|a Date Revised 31.07.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a © 2022 The Authors New Phytologist © 2022 New Phytologist Foundation.
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|a Sensing carbohydrate availability is essential for plants to coordinate their growth and development. In Arabidopsis thaliana, TREHALOSE 6-PHOSPHATE SYNTHASE 1 (TPS1) and its product, trehalose 6-phosphate (T6P), are important for the metabolic control of development. tps1 mutants are embryo-lethal and unable to flower when embryogenesis is rescued. T6P regulates development in part through inhibition of SUCROSE NON-FERMENTING1 RELATED KINASE1 (SnRK1). Here, we explored the role of SnRK1 in T6P-mediated plant growth and development using a combination of a mutant suppressor screen and genetic, cellular and transcriptomic approaches. We report nonsynonymous amino acid substitutions in the catalytic KIN10 and regulatory SNF4 subunits of SnRK1 that can restore both embryogenesis and flowering of tps1 mutant plants. The identified SNF4 point mutations disrupt the interaction with the catalytic subunit KIN10. Contrary to the common view that the two A. thaliana SnRK1 catalytic subunits act redundantly, we found that loss-of-function mutations in KIN11 are unable to restore embryogenesis and flowering, highlighting the important role of KIN10 in T6P signalling
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a Arabidopsis thaliana
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| 650 |
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4 |
|a SnRK1 complex
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| 650 |
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4 |
|a T6P pathway
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| 650 |
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4 |
|a TPS1
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| 650 |
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4 |
|a embryogenesis
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| 650 |
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4 |
|a flowering time
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| 650 |
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7 |
|a Arabidopsis Proteins
|2 NLM
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| 650 |
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|a KIN10 protein, Arabidopsis
|2 NLM
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| 650 |
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|a Phosphates
|2 NLM
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| 650 |
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7 |
|a Sugar Phosphates
|2 NLM
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| 650 |
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7 |
|a Transcription Factors
|2 NLM
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| 650 |
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7 |
|a Trehalose
|2 NLM
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| 650 |
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7 |
|a B8WCK70T7I
|2 NLM
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| 650 |
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7 |
|a Protein Serine-Threonine Kinases
|2 NLM
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| 650 |
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7 |
|a EC 2.7.11.1
|2 NLM
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| 650 |
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7 |
|a SnRK1 protein, Arabidopsis
|2 NLM
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| 650 |
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7 |
|a EC 2.7.11.1
|2 NLM
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| 700 |
1 |
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|a Ponnu, Jathish
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Crepin, Nathalie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Langenecker, Tobias
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hagmann, Jörg
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Skorzinski, Noemi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Musialak-Lange, Magdalena
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wahl, Vanessa
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rolland, Filip
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Schmid, Markus
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t The New phytologist
|d 1979
|g 235(2022), 1 vom: 20. Juli, Seite 220-233
|w (DE-627)NLM09818248X
|x 1469-8137
|7 nnas
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| 773 |
1 |
8 |
|g volume:235
|g year:2022
|g number:1
|g day:20
|g month:07
|g pages:220-233
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| 856 |
4 |
0 |
|u http://dx.doi.org/10.1111/nph.18104
|3 Volltext
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|a GBV_ILN_350
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|a AR
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|d 235
|j 2022
|e 1
|b 20
|c 07
|h 220-233
|