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20231225235456.0 |
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cr uuu---uuuuu |
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231225s2022 xx |||||o 00| ||eng c |
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7 |
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|a 10.1016/j.clim.2022.108963
|2 doi
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| 028 |
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2 |
|a pubmed24n1126.xml
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|a (DE-627)NLM337904723
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|a (NLM)35259543
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|a (PII)S1521-6616(22)00043-2
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Wong, Matthew K
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Convergent CDR3 homology amongst Spike-specific antibody responses in convalescent COVID-19 subjects receiving the BNT162b2 vaccine
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| 264 |
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1 |
|c 2022
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 18.04.2022
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|a Date Revised 05.05.2023
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|a published: Print-Electronic
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|a ErratumIn: Clin Immunol. 2023 Jun;251:109246. - PMID 37147236
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| 500 |
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright © 2022. Published by Elsevier Inc.
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| 520 |
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|a Convalescent coronavirus disease 2019 (COVID-19) subjects who receive BNT162b2 develop robust antibody responses against SARS-CoV-2. However, our understanding of the clonal B cell response pre- and post-vaccination in such individuals is limited. Here we characterized B cell phenotypes and the BCR repertoire after BNT162b2 immunization in two convalescent COVID-19 subjects. BNT162b2 stimulated many B cell clones that were under-represented during SARS-CoV-2 infection. In addition, the vaccine generated B cell clusters with >65% similarity in CDR3 VH and VL region consensus sequences both within and between subjects. This result suggests that the CDR3 region plays a dominant role adjacent to heavy and light chain V/J pairing in the recognition of the SARS-CoV-2 spike protein. Antigen-specific B cell populations with homology to published SARS-CoV-2 antibody sequences from the CoV-AbDab database were observed in both subjects. These results point towards the development of convergent antibody responses against the virus in different individuals
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Antibodies
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| 650 |
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4 |
|a B cells
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| 650 |
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4 |
|a COVID19
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| 650 |
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4 |
|a SARS CoV2
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| 650 |
|
7 |
|a Antibodies, Viral
|2 NLM
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| 650 |
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7 |
|a Complementarity Determining Regions
|2 NLM
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| 650 |
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7 |
|a Spike Glycoprotein, Coronavirus
|2 NLM
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| 650 |
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7 |
|a spike protein, SARS-CoV-2
|2 NLM
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| 650 |
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7 |
|a BNT162 Vaccine
|2 NLM
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| 650 |
|
7 |
|a N38TVC63NU
|2 NLM
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| 700 |
1 |
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|a Liu, Jun T
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Budylowksi, Patrick
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yue, Feng Yun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Zhijie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rini, James M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Carlyle, James R
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zia, Amin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ostrowski, Mario
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Martin, Alberto
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 237(2022) vom: 01. Apr., Seite 108963
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:237
|g year:2022
|g day:01
|g month:04
|g pages:108963
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| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2022.108963
|3 Volltext
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 237
|j 2022
|b 01
|c 04
|h 108963
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