The development of multicistronic vectors enabling differential transgene expression is a goal of gene therapy and poses a significant engineering challenge. Current approaches rely on the insertion of long regulatory sequences that occupy valuable space in vectors, which have a finite and limited p...
Bibliographische Detailangaben
| Veröffentlicht in: | BioTechniques. - 1991. - 72(2022), 4 vom: 27. Apr., Seite 143-154
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| 1. Verfasser: |
Sillibourne, James E
(VerfasserIn) |
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| Weitere Verfasser: |
Agliardi, Giulia,
Righi, Matteo,
Smetanova, Katerina,
Rowley, Grant,
Speller, Simon,
Dolor, Abigail,
Lamb, Katarina,
Allen, Christopher,
Karattil, Rajeev,
Parekh, Farhaan,
Vargas, Frederick Arce,
Thomas, Simon,
Cordoba, Shaun,
Pule, Martin |
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| Format: | Online-Aufsatz
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| Sprache: | English |
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| Veröffentlicht: |
2022
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| Zugriff auf das übergeordnete Werk: | BioTechniques
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| Schlagworte: | Journal Article
Research Support, Non-U.S. Gov't
T cell
cancer
chimeric antigen receptor
differential transgene expression
immunotherapy
packaging limit
translational readthrough motif
ultra-low expression
Codon, Terminator |
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