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231225s2022 xx |||||o 00| ||eng c |
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|a 10.1016/j.nima.2021.166077
|2 doi
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|a pubmed24n1511.xml
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|a (NLM)35221402
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|a (PII)166077
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|a DE-627
|b ger
|c DE-627
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|a eng
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1 |
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|a Darne, Chinmay D
|e verfasserin
|4 aut
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|a A novel proton-integrating radiography system design using a monolithic scintillator detector
|b experimental studies
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|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Revised 24.08.2024
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|a published: Print-Electronic
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|a Citation Status PubMed-not-MEDLINE
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|a Research on proton-based imaging systems aims to improve treatment planning, internal anatomy visualization, and patient alignment for proton radiotherapy. The purpose of this study was to demonstrate a new proton radiography system design consisting of a monolithic plastic scintillator volume and two optical cameras for use with scanning proton pencil beams. Unlike the thin scintillating plates currently used for proton radiography, the plastic scintillator volume (20 × 20 × 20 cm3) captures a wider distribution of proton beam energy depositions and avoids proton-beam modulation. The proton imaging system's characteristics were tested using image uniformity (2.6% over a 5 × 5 cm2 area), stability (0.37%), and linearity (R2 = 1) studies. We used the light distribution produced within the plastic scintillator to generate proton radiographs via two different approaches: (a) integrating light by using a camera placed along the beam axis, and (b) capturing changes to the proton Bragg peak positions with a camera placed perpendicularly to the beam axis. The latter method was used to plot and evaluate relative shifts in percentage depth light (PDL) profiles of proton beams with and without a phantom in the beam path. A curvelet minimization algorithm used differences in PDL profiles to reconstruct and refine the phantom water-equivalent thickness (WET) map. Gammex phantoms were used to compare the proton radiographs generated by these two methods. The relative accuracies in calculating WET of the phantoms using the calibration-based beam-integration (and the PDL) methods were -0.18 ± 0.35% (-0.29 ± 3.11%), -0.11 ± 0.51% (-0.15 ± 2.64%), -2.94 ± 1.20% (-0.75 ± 6.11%), and -1.65 ± 0.35% (0.36 ± 3.93%) for solid water, adipose, cortical bone, and PMMA, respectively. Further exploration of this unique multicamera-based imaging system is warranted and could lead to clinical applications that improve treatment planning and patient alignment for proton radiotherapy
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|a Journal Article
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|a CCD camera
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|a plastic scintillator
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|a proton radiography
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|a proton therapy
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|a Robertson, Daniel G
|e verfasserin
|4 aut
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|a Alsanea, Fahed
|e verfasserin
|4 aut
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|a Collins-Fekete, Charles-Antoine
|e verfasserin
|4 aut
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|a Beddar, Sam
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment
|d 1987
|g 1027(2022) vom: 11. März
|w (DE-627)NLM098171771
|x 0168-9002
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|u http://dx.doi.org/10.1016/j.nima.2021.166077
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