Mucus Penetrating and Cell-Binding Polyzwitterionic Micelles as Potent Oral Nanomedicine for Cancer Drug Delivery

Mucus Penetrating and Cell-Binding Polyzwitterionic Micelles as Potent Oral Nanomedicine for Cancer Drug Delivery

© 2022 Wiley-VCH GmbH.

Détails bibliographiques
Publié dans:Advanced materials (Deerfield Beach, Fla.). - 1998. - 34(2022), 16 vom: 25. Apr., Seite e2109189
Auteur principal: Fan, Wufa (Auteur)
Autres auteurs: Wei, Qiuyu, Xiang, Jiajia, Tang, Yisi, Zhou, Quan, Geng, Yu, Liu, Yanpeng, Sun, Rui, Xu, Lei, Wang, Guowei, Piao, Ying, Shao, Shiqun, Zhou, Zhuxian, Tang, Jianbin, Xie, Tao, Li, Zichen, Shen, Youqing
Format: Article en ligne
Langue:English
Publié: 2022
Accès à la collection:Advanced materials (Deerfield Beach, Fla.)
Sujets:Journal Article cancer drug delivery mucus penetrating oral nanomedicines polyzwitterionic micelles transcytosis Antineoplastic Agents Drug Carriers Micelles Polymers plus... Polyethylene Glycols 3WJQ0SDW1A Paclitaxel P88XT4IS4D
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520 |a Orally administrable anticancer nanomedicines are highly desirable due to their easy and repeatable administration, but are not yet feasible because the current nanomedicine cannot simultaneously overcome the strong mucus and villi barriers and thus have very low bioavailability (BA). Herein, this work presents the first polymeric micelle capable of fast mucus permeation and villi absorption and delivering paclitaxel (PTX) efficiently to tumors with therapeutic efficacy even better than intravenously administered polyethylene glycol based counterpart or free PTX. Poly[2-(N-oxide-N,N-diethylamino)ethyl methacrylate] (OPDEA), a water-soluble polyzwitterion, is highly nonfouling to proteins and other biomacromolecules such as mucin but can weakly bind to phospholipids. Therefore, the micelle of its block copolymer with poly(ε-caprolactone) (OPDEA-PCL) can efficiently permeate through the viscous mucus and bind to villi, which triggers transcytosis-mediated transepithelial transport into blood circulation for tumor accumulation. The orally administered micelles deliver PTX to tumors, efficiently inhibiting the growth of HepG2 and patient-derived hepatocellular carcinoma xenografts and triple-negative breast tumors. These results demonstrate that OPDEA-based micelles may serve as an efficient oral nanomedicine for delivering other small molecules or even large molecules 
650 4 |a Journal Article 
650 4 |a cancer drug delivery 
650 4 |a mucus penetrating 
650 4 |a oral nanomedicines 
650 4 |a polyzwitterionic micelles 
650 4 |a transcytosis 
650 7 |a Antineoplastic Agents  |2 NLM 
650 7 |a Drug Carriers  |2 NLM 
650 7 |a Micelles  |2 NLM 
650 7 |a Polymers  |2 NLM 
650 7 |a Polyethylene Glycols  |2 NLM 
650 7 |a 3WJQ0SDW1A  |2 NLM 
650 7 |a Paclitaxel  |2 NLM 
650 7 |a P88XT4IS4D  |2 NLM 
700 1 |a Wei, Qiuyu  |e verfasserin  |4 aut 
700 1 |a Xiang, Jiajia  |e verfasserin  |4 aut 
700 1 |a Tang, Yisi  |e verfasserin  |4 aut 
700 1 |a Zhou, Quan  |e verfasserin  |4 aut 
700 1 |a Geng, Yu  |e verfasserin  |4 aut 
700 1 |a Liu, Yanpeng  |e verfasserin  |4 aut 
700 1 |a Sun, Rui  |e verfasserin  |4 aut 
700 1 |a Xu, Lei  |e verfasserin  |4 aut 
700 1 |a Wang, Guowei  |e verfasserin  |4 aut 
700 1 |a Piao, Ying  |e verfasserin  |4 aut 
700 1 |a Shao, Shiqun  |e verfasserin  |4 aut 
700 1 |a Zhou, Zhuxian  |e verfasserin  |4 aut 
700 1 |a Tang, Jianbin  |e verfasserin  |4 aut 
700 1 |a Xie, Tao  |e verfasserin  |4 aut 
700 1 |a Li, Zichen  |e verfasserin  |4 aut 
700 1 |a Shen, Youqing  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Advanced materials (Deerfield Beach, Fla.)  |d 1998  |g 34(2022), 16 vom: 25. Apr., Seite e2109189  |w (DE-627)NLM098206397  |x 1521-4095  |7 nnas 
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