Modulating Electron Transfer in Vanadium-Based Artificial Enzymes for Enhanced ROS-Catalysis and Disinfection

Modulating Electron Transfer in Vanadium-Based Artificial Enzymes for Enhanced ROS-Catalysis and Disinfection

© 2022 Wiley-VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 34(2022), 17 vom: 21. Apr., Seite e2108646
1. Verfasser: Li, Ling (VerfasserIn)
Weitere Verfasser: Cao, Sujiao, Wu, Zihe, Guo, Ruiqian, Xie, Lan, Wang, Liyun, Tang, Yuanjiao, Li, Qi, Luo, Xianglin, Ma, Lang, Cheng, Chong, Qiu, Li
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2022
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article ROS-based biocatalysis antibacterial and wound healing artificial enzymes electron modulation inorganic nanomaterials Reactive Oxygen Species Vanadium 00J9J9XKDE
Beschreibung
Zusammenfassung:© 2022 Wiley-VCH GmbH.
Nanomaterials-based artificial enzymes (AEs) have flourished for more than a decade. However, it is still challenging to further enhance their biocatalytic performances due to the limited strategies to tune the electronic structures of active centers. Here, a new path is reported for the de novo design of the d electrons of active centers by modulating the electron transfer in vanadium-based AEs (VOx -AE) via a unique Zn-O-V bridge for efficient reactive oxygen species (ROS)-catalysis. Benefiting from the electron transfer from Zn to V, the V site in VOx -AE exhibits a lower valence state than that in V2 O5 , which results in charge-filled V-dyz orbital near the Fermi level to interfere with the formation of sigma bonds between the V- d z 2 and O-pz orbitals in H2 O2 . The VOx -AE exhibits a twofold Vmax and threefold turnover number than V2 O5 when catalyzing H2 O2 . Meanwhile, the VOx -AE shows enhanced catalytic eradication of drug-resistant bacteria and achieves comparable wound-treatment indexes to vancomycin. This modulating charge-filling of d electrons provides a new direction for the de novo design of nanomaterials-based AEs and deepens the understanding of ROS-catalysis
Beschreibung:Date Completed 28.04.2022
Date Revised 28.04.2022
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.202108646