Open-Shell Nanosensitizers for Glutathione Responsive Cancer Sonodynamic Therapy

Open-Shell Nanosensitizers for Glutathione Responsive Cancer Sonodynamic Therapy

© 2022 The Authors. Advanced Materials published by Wiley-VCH GmbH.

Détails bibliographiques
Publié dans:Advanced materials (Deerfield Beach, Fla.). - 1998. - 34(2022), 15 vom: 01. Apr., Seite e2110283
Auteur principal: Wang, Han (Auteur)
Autres auteurs: Guo, Jinxiao, Lin, Wilson, Fu, Zi, Ji, Xiuru, Yu, Bo, Lu, Min, Cui, Wenguo, Deng, Lianfu, Engle, Jonathan W, Wu, Zhiyuan, Cai, Weibo, Ni, Dalong
Format: Article en ligne
Langue:English
Publié: 2022
Accès à la collection:Advanced materials (Deerfield Beach, Fla.)
Sujets:Journal Article glutathione response nanomedicine open shell positron emission tomography imaging sonodynamic therapy Porphyrins Polyethylene Glycols 3WJQ0SDW1A Glutathione GAN16C9B8O
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520 |a Deleterious effects to normal tissues and short biological half-life of sonosensitizers limit the applications of sonodynamic therapy (SDT). Herein, a new sonosensitizer (Cu(II)NS) is synthesized that consists of porphyrins, chelated Cu2+ , and poly(ethylene glycol) (PEG) to overcome the challenges of SDT. As Cu2+ contains 27 electrons, Cu(II)NS has an unpaired electron (open shell), resulting in a doublet ground state and little sonosensitivity. Overexpressed glutathione in the tumor can reduce Cu2+ to generate Cu(I)NS, leading to a singlet ground state and recuperative sonosensitivity. Additionally, PEG endows Cu(II)NS with increased blood biological half-life and enhanced tumor accumulation, further increasing the effect of SDT. Through regulating the valence state of Cu, cancer SDT with enhanced therapeutic index is achieved 
650 4 |a Journal Article 
650 4 |a glutathione response 
650 4 |a nanomedicine 
650 4 |a open shell 
650 4 |a positron emission tomography imaging 
650 4 |a sonodynamic therapy 
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650 7 |a Polyethylene Glycols  |2 NLM 
650 7 |a 3WJQ0SDW1A  |2 NLM 
650 7 |a Glutathione  |2 NLM 
650 7 |a GAN16C9B8O  |2 NLM 
700 1 |a Guo, Jinxiao  |e verfasserin  |4 aut 
700 1 |a Lin, Wilson  |e verfasserin  |4 aut 
700 1 |a Fu, Zi  |e verfasserin  |4 aut 
700 1 |a Ji, Xiuru  |e verfasserin  |4 aut 
700 1 |a Yu, Bo  |e verfasserin  |4 aut 
700 1 |a Lu, Min  |e verfasserin  |4 aut 
700 1 |a Cui, Wenguo  |e verfasserin  |4 aut 
700 1 |a Deng, Lianfu  |e verfasserin  |4 aut 
700 1 |a Engle, Jonathan W  |e verfasserin  |4 aut 
700 1 |a Wu, Zhiyuan  |e verfasserin  |4 aut 
700 1 |a Cai, Weibo  |e verfasserin  |4 aut 
700 1 |a Ni, Dalong  |e verfasserin  |4 aut 
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773 1 8 |g volume:34  |g year:2022  |g number:15  |g day:01  |g month:04  |g pages:e2110283 
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