An Engineered Protein-Au Bioplaster for Efficient Skin Tumor Therapy

Bibliographische Detailangaben
Veröffentlicht in:	Advanced materials (Deerfield Beach, Fla.). - 1998. - 34(2022), 16 vom: 06. Apr., Seite e2110062
1. Verfasser:	Wei, Zheng (VerfasserIn)
Weitere Verfasser:	Sun, Jing, Lu, Shuang, Liu, Yawei, Wang, Bo, Zhao, Lai, Wang, Zili, Liu, Kai, Li, Jingjing, Su, Juanjuan, Wang, Fan, Zhang, Hongjie, Yang, Yang
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2022
Zugriff auf das übergeordnete Werk:	Advanced materials (Deerfield Beach, Fla.)
Schlagworte:	Journal Article adhesive proteins bioplasters gold nanoparticles photothermal effect skin cancer therapy Polypyrimidine Tract-Binding Protein 139076-35-0 Gold 7440-57-5

Beschreibung
Zusammenfassung:	© 2022 Wiley-VCH GmbH. Melanoma is the most lethal malignancy in skin cancer and may occur at any site and express melanocytes. Due to malignant melanoma's invasion and migration nature, conventional therapies make it challenging to remove the whole tumor tissue while undertaking the high risks of tumor recurrence. Regarding the emerging targeted therapies and immunotherapy, drug resistance and low immunotherapeutic activity remain significant challenges. It is thus becoming urgently important to develop alternative strategies for melanoma therapy. Herein, a novel bifunctional protein-based photothermal bioplaster (PPTB) is developed for non-invasive tumor therapy and skin tissue regeneration. The complexation of adhesive protein and gold nanorods (GNRs) endow the obtained PPTB with good biocompatibility, controllable near-infrared (NIR) light-mediated adhesion performance, and high photothermal performance. Therefore, the PPTB bioagent facilitates skin adhesion and effectively transfers heat from skin to tumor. This behavior endows PPTB capability to eradicate skin tumors conveniently. Thus, the assembly strategy enables this hybrid bioplaster to hold great potential for skin-related tumor treatment
Beschreibung:	Date Completed 22.04.2022 Date Revised 22.04.2022 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-4095
DOI:	10.1002/adma.202110062