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231225s2022 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.1c02978
|2 doi
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
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|a Koga, Tomoyuki
|e verfasserin
|4 aut
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| 245 |
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|a Narcissistic Self-Sorting of Amphiphilic Collagen-Inspired Peptides in Supramolecular Vesicular Assembly
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|c 2022
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|a Text
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 08.03.2022
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|a Date Revised 08.03.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Herein, we describe the hierarchical self-assembly accompanying self-sorting of collagen-inspired peptides (CPs). The two amphiphilic CPs used in this study contained an azobenzene (Az) moiety at the N-terminal, connected through a flexible spacer, but with different lengths of the (Gly-Pro-Hyp)n triplet (n = 5 and 7). When the CP aqueous solution (60 °C) was cooled to 4 °C, both CPs formed a triple helix structure and the pre-organized helices subsequently self-assembled into highly ordered vesicles with a diameter of 50-200 nm. Interestingly, narcissistic self-sorting was observed in both triple helix- and matured vesicle-formation processes, when the two CPs were mixed. Owing to the difference in the propensity for triple helix formation with temperature, the two CPs discriminate each other in response to a temperature change and form two kinds of triple helix foldamers, each containing a single component. The resulting differences in the amphiphilic balance and molecular length between the foldamers appear to allow individual self-sorting to form distinct vesicles. Furthermore, such vesicular assemblies were found to disassemble upon UV irradiation via trans-cis isomerization of the Az-groups. These findings offer important insights into the design of new complex but ordered, peptide self-assembly systems with potential applications in nanobiotechnology
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Peptides
|2 NLM
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|a Collagen
|2 NLM
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|a 9007-34-5
|2 NLM
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|a Ikejiri, Aika
|e verfasserin
|4 aut
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|a Higashi, Nobuyuki
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 38(2022), 7 vom: 22. Feb., Seite 2294-2300
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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|g volume:38
|g year:2022
|g number:7
|g day:22
|g month:02
|g pages:2294-2300
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|u http://dx.doi.org/10.1021/acs.langmuir.1c02978
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