Subcutaneous Gammanorm® by pump or rapid push infusion Impact of the device on quality of life in adult patients with primary immunodeficiencies

Subcutaneous Gammanorm® by pump or rapid push infusion : Impact of the device on quality of life in adult patients with primary immunodeficiencies

Copyright © 2022. Published by Elsevier Inc.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 236(2022) vom: 02. März, Seite 108938
1. Verfasser: Warnatz, Klaus (VerfasserIn)
Weitere Verfasser: Jolles, Stephen, Agostini, Carlo, Vianello, Fabrizio, Borte, Michael, Bethune, Claire, Grigoriadou, Sofia, Richter, Alex, Jain, Rashmi, Lowe, David M, Katelaris, Constance, Milito, Cinzia, Cook, Matthew C
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2022
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Multicenter Study Randomized Controlled Trial Research Support, Non-U.S. Gov't Immunoglobulin replacement therapy Primary immunodeficiency Quality of life Rapid push Self-treatment Immunoglobulin G
Beschreibung
Zusammenfassung:Copyright © 2022. Published by Elsevier Inc.
Many patients with immunodeficiencies require lifelong immunoglobulin replacement therapy (IgRT). In a multicenter, randomized, open-label, crossover, non-inferiority 3-month-trial, we compared the impact of the subcutaneous immunoglobulin Gammanorm® administered via pump or syringe (rapid push). Primary endpoint was the life quality index (LQI), secondary endpoints were QoL (SF36v2), satisfaction (TSQM-11), disease and treatment burden (PRISM), incidence of infections and adverse events (AE), treatment costs, and IgG levels. 28/30 patients completed the study. Most of the endpoints were comparable. Drug administrations with rapid push were more frequent, but reduced total time expenditure and some costs. Of the TSQM-11/LQI/SF36 components only "treatment interference with daily activities" was superior with pump and two QoL domains with rapid push. Both delivery devices showed favorable safety. Rapid push was preferred by 34.5% of patients. It proved to be an efficacious and cost-effective alternative to pumps adding to patient choice and increasing flexibility during long-term IgRT
Beschreibung:Date Completed 06.05.2022
Date Revised 06.05.2022
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2022.108938