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231225s2022 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202109522
|2 doi
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|a pubmed24n1121.xml
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|a eng
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|a Yang, Ming
|e verfasserin
|4 aut
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|a Urine-Microenvironment-Initiated Composite Hydrogel Patch Reconfiguration Propels Scarless Memory Repair and Reinvigoration of the Urethra
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|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 08.04.2022
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|a Date Revised 08.04.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2022 Wiley-VCH GmbH.
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|a The harsh urine microenvironment (UME), as an inherent hurdle, endangers and renders urethral repair unreachable. Innovatively, the unfavorable UME is utilized as the design source to construct a UME-responsive 3D-printed hydrogel patch for realizing scarless memory repair, wherein laser-excited reactive oxygen species (ROS) production and mechanical strength elevation using chemically crosslinked silicon quantum dots are accessible. Intriguingly, the proposed composite scaffolds can respond to Ca2+ in urine, cause structure reconfiguration, and repress swelling to further enhance scaffold stiffness. Systematic experiments validate that ROS birth and unexpected stiffness elevation in such UME-responsive scaffolds can realize scarless memory repair of the urethra in vivo. Comprehensive mechanism explorations uncover that the activations of cell proliferation and collagen-related genes (e.g., MMP-1 and COL3A1) and the dampening of fibrosis-related (e.g., TGF-β/Smad) and mechanosensitive genes (e.g., YAP/TAZ) are responsible for the scarless memory repair of such UME-responsive scaffolds via enhancing collagen deposition, recalling mechanical memory, decreasing fibrosis and inflammation, and accelerating angiogenesis. The design rationales (e.g., UME-initiated structure reconfiguration and antiswelling) can serve as an instructive and general approach for urethra repair
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|a Journal Article
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|a antiswelling
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|a mechanical strength
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|a scarless memory repair
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|a structure reconfiguration
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|a urine microenvironment
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|a Hydrogels
|2 NLM
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|a Reactive Oxygen Species
|2 NLM
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1 |
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|a Zhang, Yang
|e verfasserin
|4 aut
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1 |
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|a Fang, Chao
|e verfasserin
|4 aut
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1 |
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|a Song, Li
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Ying
|e verfasserin
|4 aut
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|a Lu, Lu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Ranxing
|e verfasserin
|4 aut
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|a Bu, Zhaoting
|e verfasserin
|4 aut
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| 700 |
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|a Liang, Xiayi
|e verfasserin
|4 aut
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|a Zhang, Kun
|e verfasserin
|4 aut
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| 700 |
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|a Fu, Qiang
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 34(2022), 14 vom: 01. Apr., Seite e2109522
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|g year:2022
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|g pages:e2109522
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|u http://dx.doi.org/10.1002/adma.202109522
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