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231225s2022 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202110352
|2 doi
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|a pubmed25n1121.xml
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Zhang, Xiangyun
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Biomimetic Design of Artificial Hybrid Nanocells for Boosted Vascular Regeneration in Ischemic Tissues
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|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 08.04.2022
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|a Date Revised 08.04.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2022 Wiley-VCH GmbH.
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|a Restoration of sufficient blood supply for the treatment of ischemia remains a significant scientific and clinical challenge. Here, a cell-like nanoparticle delivery technology is introduced that is capable of recapitulating multiple cell functions for the spatiotemporal triggering of vascular regeneration. Specifically, a copper-containing protein is successfully prepared using a recombinant protein scaffold based on a de novo design strategy, which facilitates the timely release of nitric oxide and improved accumulation of particles within ischemic tissues. Through closely mimicking physiological cues, the authors demonstrate the benefits of bioactive factors secreted from hypoxic stem cells on promoting angiogenesis. Following this cell-mimicking manner, artificial hybrid nanosized cells (Hynocell) are constructed by integrating the hypoxic stem cell secretome into nanoparticles with surface coatings of cell membranes fused with copper-containing protein. The Hynocell, hybridized with different cell-derived components, provides synergistic effects on targeting ischemic tissues and promoting vascular regeneration in acute hindlimb ischemia and acute myocardial infarction models. This study offers new insights into the utilization of nanotechnology to potentiate the development of cell-free therapeutics
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|a Journal Article
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|a cell-like delivery
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|a ferritin
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|a ischemic diseases
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|a nitric oxide
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|a vascular regeneration
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|a Copper
|2 NLM
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| 650 |
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|a 789U1901C5
|2 NLM
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| 700 |
1 |
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|a Zhang, Yue
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Ran
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jiang, Xinbang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Midgley, Adam C
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Qiqi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kang, Helong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wu, Jin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Khalique, Anila
|e verfasserin
|4 aut
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| 700 |
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|a Qian, Meng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a An, Di
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Huang, Jing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ou, Lailiang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhao, Qiang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhuang, Jie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yan, Xiyun
|e verfasserin
|4 aut
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| 700 |
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|a Kong, Deling
|e verfasserin
|4 aut
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| 700 |
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|a Huang, Xinglu
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 34(2022), 14 vom: 04. Apr., Seite e2110352
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
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| 773 |
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|g volume:34
|g year:2022
|g number:14
|g day:04
|g month:04
|g pages:e2110352
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| 856 |
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|u http://dx.doi.org/10.1002/adma.202110352
|3 Volltext
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