Hybrid-Membrane-Decorated Prussian Blue for Effective Cancer Immunotherapy via Tumor-Associated Macrophages Polarization and Hypoxia Relief

© 2022 Wiley-VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 34(2022), 14 vom: 01. Apr., Seite e2200389
1. Verfasser: Hou, Lin (VerfasserIn)
Weitere Verfasser: Gong, Xuan, Yang, Jing, Zhang, Huijuan, Yang, Weijing, Chen, Xiaoyuan
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2022
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article cancer immunotherapy hollow mesoporous Prussian blue hybrid membranes hydroxychloroquine tumor-associated macrophages Ferrocyanides Mannose PHA4727WTP ferric ferrocyanide TLE294X33A
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520 |a Both tumor-associated macrophages (TAMs) and hypoxia condition severely restrict the antitumor potency during cancer immunotherapy. It is essential to overcome the two issues for improving therapeutic efficacy. In this study, a hollow mesoporous Prussian blue (HMPB) nanosystem with mannose decoration and hydroxychloroquine (HCQ) adsorption is built, to form Man-HMPB/HCQ. It can facilitate cellular internalization via mannose-receptor mediated endocytosis and induce TAM polarization via iron ion/HCQ release with HMPB degradation. The hybrid macrophage and thylakoid (TK) membrane is camouflaged on the Man-HMPB/HCQ surface, denoted as TK-MMan-HMPB/HCQ, to reduce in vivo reticuloendothelial system uptake, enhance tumor accumulation, and mitigate hypoxia. The in vivo results indicate that TK-M@Man-HMPB/HCQ notably inhibits tumor growth, induces TAM polarization, facilitates cytotoxic T lymphocytes infiltration, and alleviates hypoxia microenvironment. The rational design may provide a new pathway to modulate the tumor microenvironment for promoting cancer immunotherapy effects 
650 4 |a Journal Article 
650 4 |a cancer immunotherapy 
650 4 |a hollow mesoporous Prussian blue 
650 4 |a hybrid membranes 
650 4 |a hydroxychloroquine 
650 4 |a tumor-associated macrophages 
650 7 |a Ferrocyanides  |2 NLM 
650 7 |a Mannose  |2 NLM 
650 7 |a PHA4727WTP  |2 NLM 
650 7 |a ferric ferrocyanide  |2 NLM 
650 7 |a TLE294X33A  |2 NLM 
700 1 |a Gong, Xuan  |e verfasserin  |4 aut 
700 1 |a Yang, Jing  |e verfasserin  |4 aut 
700 1 |a Zhang, Huijuan  |e verfasserin  |4 aut 
700 1 |a Yang, Weijing  |e verfasserin  |4 aut 
700 1 |a Chen, Xiaoyuan  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Advanced materials (Deerfield Beach, Fla.)  |d 1998  |g 34(2022), 14 vom: 01. Apr., Seite e2200389  |w (DE-627)NLM098206397  |x 1521-4095  |7 nnas 
773 1 8 |g volume:34  |g year:2022  |g number:14  |g day:01  |g month:04  |g pages:e2200389 
856 4 0 |u http://dx.doi.org/10.1002/adma.202200389  |3 Volltext 
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