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231225s2022 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202200389
|2 doi
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|a pubmed25n1121.xml
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|a DE-627
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|a eng
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|a Hou, Lin
|e verfasserin
|4 aut
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|a Hybrid-Membrane-Decorated Prussian Blue for Effective Cancer Immunotherapy via Tumor-Associated Macrophages Polarization and Hypoxia Relief
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|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 08.04.2022
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|a Date Revised 08.04.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2022 Wiley-VCH GmbH.
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|a Both tumor-associated macrophages (TAMs) and hypoxia condition severely restrict the antitumor potency during cancer immunotherapy. It is essential to overcome the two issues for improving therapeutic efficacy. In this study, a hollow mesoporous Prussian blue (HMPB) nanosystem with mannose decoration and hydroxychloroquine (HCQ) adsorption is built, to form Man-HMPB/HCQ. It can facilitate cellular internalization via mannose-receptor mediated endocytosis and induce TAM polarization via iron ion/HCQ release with HMPB degradation. The hybrid macrophage and thylakoid (TK) membrane is camouflaged on the Man-HMPB/HCQ surface, denoted as TK-MMan-HMPB/HCQ, to reduce in vivo reticuloendothelial system uptake, enhance tumor accumulation, and mitigate hypoxia. The in vivo results indicate that TK-M@Man-HMPB/HCQ notably inhibits tumor growth, induces TAM polarization, facilitates cytotoxic T lymphocytes infiltration, and alleviates hypoxia microenvironment. The rational design may provide a new pathway to modulate the tumor microenvironment for promoting cancer immunotherapy effects
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|a Journal Article
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|a cancer immunotherapy
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|a hollow mesoporous Prussian blue
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|a hybrid membranes
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|a hydroxychloroquine
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|a tumor-associated macrophages
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|a Ferrocyanides
|2 NLM
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|a Mannose
|2 NLM
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|a PHA4727WTP
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|a ferric ferrocyanide
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|a TLE294X33A
|2 NLM
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| 700 |
1 |
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|a Gong, Xuan
|e verfasserin
|4 aut
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1 |
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|a Yang, Jing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Huijuan
|e verfasserin
|4 aut
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| 700 |
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|a Yang, Weijing
|e verfasserin
|4 aut
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|a Chen, Xiaoyuan
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 34(2022), 14 vom: 01. Apr., Seite e2200389
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
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| 773 |
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|g volume:34
|g year:2022
|g number:14
|g day:01
|g month:04
|g pages:e2200389
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|u http://dx.doi.org/10.1002/adma.202200389
|3 Volltext
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