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231225s2022 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202110614
|2 doi
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|a pubmed24n1120.xml
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|a eng
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| 100 |
1 |
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|a Wang, Yuqi
|e verfasserin
|4 aut
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|a Bioinspired Lipoproteins of Furoxans-Oxaliplatin Remodel Physical Barriers in Tumor to Potentiate T-Cell Infiltration
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|c 2022
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|a Text
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 08.04.2022
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|a Date Revised 08.04.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2022 Wiley-VCH GmbH.
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|a The infiltration of cytotoxic T lymphocytes (CTLs) in tumors is critically challenged by the intricate intratumor physical barriers, which is emerging as an important issue of anticancer immunotherapy. Herein, a reduction-sensitive nitric oxide donor conjugate of furoxans-oxaliplatin is synthesized and a stroma-cell-accessible bioinspired lipoprotein system (S-LFO) is designed, aiming to facilitate CTL infiltration in tumors for anticancer immunotherapy. S-LFO treatment significantly promotes tumor vessel normalization and eliminates multiple components of tumor stroma, ultimately producing a 2.96-fold, 5.02-fold, and 8.65-fold increase of CD3+ CD8+ T cells, their interferon-γ- and granzyme B-expressing subtypes when comparing to the negative control, and considerably facilitating their trafficking to the cancer cell regions in tumors. Moreover, the combination of S-LFO with an antiprogrammed death ligand-1 produces notable therapeutic benefits of retarded tumor growth and extends survivals in three murine tumor models. Therefore, this study provides an encouraging strategy of remodeling the intratumor physical barriers to potentiate CTL infiltration for anticancer immunotherapy
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|a Journal Article
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|a bioinspired lipoprotein
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|a lymphocyte infiltration
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|a nitric oxide
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|a tumor stroma barrier
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|a tumor vessel normalization
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|a Lipoproteins
|2 NLM
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|a Oxadiazoles
|2 NLM
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| 650 |
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|a furoxans
|2 NLM
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|a Oxaliplatin
|2 NLM
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| 650 |
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|a 04ZR38536J
|2 NLM
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| 700 |
1 |
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|a Xie, Honglei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wu, Yao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xu, Shuzhou
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Yongping
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Jie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xu, Xiaoxuan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Siling
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Yaping
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Zhiwen
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
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|g 34(2022), 14 vom: 05. Apr., Seite e2110614
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|g volume:34
|g year:2022
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|g pages:e2110614
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|u http://dx.doi.org/10.1002/adma.202110614
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