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|a 10.3760/cma.j.cn112140-20210625-00532
|2 doi
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|a chi
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|a Zhao, P
|e verfasserin
|4 aut
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|a Non-erythrocyte blood products transfusion in very preterm and extremely preterm infants in Chinese neonatal intensive care units
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|c 2022
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|a Text
|b txt
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|a ƒaComputermedien
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|a Date Completed 01.02.2022
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|a Date Revised 01.02.2022
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|a published: Print
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|a Citation Status MEDLINE
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|a Objective: To describe the use of non-erythrocyte blood products transfusion in very preterm and extremely preterm infants in the neonatal intensive care units (NICU) of the Chinese Neonatal Network (CHNN) in 2019, to explore the disparity between different centers, and to further investigate the rationality and standardability of non-erythrocyte blood products transfusion. Methods: This was a cross-sectional study based on the CHNN cohort of very preterm and extremely preterm infants. All 6 598 infants with gestational age (GA)<32 weeks and admitted to the 57 NICU of CHNN within 24 h of life in 2019 were enrolled. Non-erythrocyte blood products included platelet, plasma, albumin, immunoglobulin, cryoprecipitate and prothrombin complex. Infants who received at least one type of non-erythrocyte blood products were defined in transfusion group. The comparison between infants with and without transfusion was done by t-test, rank-sum test or χ2 test as appropriate. Linear regression model was used to generate adjusted transfusion rate of each center, and to investigate the correlation between adjusted rate and center-level characteristics. Results: A total of 6 598 infants were enrolled in the study, with gestational age of 30.0 (28.7, 31.0) weeks and birth weight of (1 353±312) g, and 43.6 % (2 877) of them were female. Among them, 42.7% (2 816) infants were enrolled in transfusion group, with the times of transfusion as 3 (1, 6) times. Compared to the infants without any transfusion of non-erythrocyte blood products, those infants received transfusion had lower gestational age (Z=17.62, P<0.01), lower birth weight (t=18.64, P<0.01), higher proportion of small-for-gestation age (χ2=31.06, P<0.01), multiple birth (χ²=12.82, P<0.01) and intensive resuscitation in delivery room (χ²=287.52, P<0.01), as well as lower proportion of females (χ²=10.68, P<0.01) and even lower proportion of infants born in this hospital (χ²=78.23, P<0.01). Among the entire study population, albumin (25.4%, 1 674 cases), immunoglobulin (21.5%, 1 417 cases) and plasma (18.9%, 1 245 cases) were the most commonly used non-erythrocyte blood products. Overall, 60.4% (544/901) infants with gestational age <28 weeks received transfusion 4 (2, 8) times. A total of 39.9% (2 272/5 697) infants between 28-31weeks received non-erythrocyte blood products 3 (1, 6) times. The non-erythrocyte blood products transfusion rates of critically-ill and non-critically-ill infants were 62.2% (1 693/2 723) and 29.0% (1 123/3 875) respectively, and the transfusion times were 4 (2,7) and 2 (1,4) times. The transfusion rates varied significantly among different NICU, and the disparities remained obvious after adjustment (adjusted χ²=153.48, P<0.01). Conclusion: Near half of very preterm and extremely preterm infants admitted to Chinese NICU in 2019 receive non-erythrocyte blood products during hospitalization with significant disparities among different hospitals
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|a Journal Article
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|a Gu, X Y
|e verfasserin
|4 aut
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|a Jiang, S Y
|e verfasserin
|4 aut
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|a Wang, Y C
|e verfasserin
|4 aut
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1 |
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|a Cao, Y
|e verfasserin
|4 aut
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|a Zhou, W H
|e verfasserin
|4 aut
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|a Lee, K
|e verfasserin
|4 aut
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|a Zhang, Q
|e verfasserin
|4 aut
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|a Wang, Jin
|e verfasserin
|4 aut
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| 700 |
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|a Chinese Neonatal Network
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Zhonghua er ke za zhi = Chinese journal of pediatrics
|d 1960
|g 60(2022), 2 vom: 02. Feb., Seite 94-100
|w (DE-627)NLM136249191
|x 0578-1310
|7 nnns
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| 773 |
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|g volume:60
|g year:2022
|g number:2
|g day:02
|g month:02
|g pages:94-100
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|u http://dx.doi.org/10.3760/cma.j.cn112140-20210625-00532
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