Construction of a Molybdenum Disulfide-Based Colorimetric Sensor for Label-Free Infectious Disease Analysis Coupled with a Catalyzed Hairpin Assembly Reaction

The simple and accurate determination of pathogenic infectious diseases is very beneficial to public health prevention and control. For this purpose, we designed a colorimetric sensor for label-free avian influenza A (H7N9) virus gene sequence detection based on goldplatinum core-shell bimetallic-na...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 38(2022), 5 vom: 08. Feb., Seite 1791-1796
1. Verfasser: Dong, Yan (VerfasserIn)
Weitere Verfasser: Wan, Ling, Lv, Suo, Zhu, Dan, Su, Shao, Chao, Jie, Wang, Lianhui
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2022
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Disulfides Gold 7440-57-5 Molybdenum 81AH48963U Hydrogen Peroxide BBX060AN9V Peroxidases mehr... EC 1.11.1.- molybdenum disulfide ZC8B4P503V
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245 1 0 |a Construction of a Molybdenum Disulfide-Based Colorimetric Sensor for Label-Free Infectious Disease Analysis Coupled with a Catalyzed Hairpin Assembly Reaction 
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520 |a The simple and accurate determination of pathogenic infectious diseases is very beneficial to public health prevention and control. For this purpose, we designed a colorimetric sensor for label-free avian influenza A (H7N9) virus gene sequence detection based on goldplatinum core-shell bimetallic-nanoparticle-decorated molybdenum disulfide (MoS2-Au@Pt) nanocomposites. MoS2-Au@Pt nanocomposites were used as nanoenzymes to catalyze 3,3',5,5'-tetramethylbenzidine (TMB) by hydrogen peroxide (H2O2) because of their intrinsic peroxidase-mimicking activity. Coupled with different affinities of MoS2-Au@Pt nanocomposites toward single-stranded (ss) and double-stranded (ds) DNA and the target-triggered catalyzed hairpin assembly (CHA) reaction, the proposed sensor can qualitatively and quantitatively determine H7N9 by the naked eye. Experimental results showed that this sensor can detect H7N9 in buffer and real samples because of its high sensitivity, selectivity, and repeatability 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
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650 7 |a Hydrogen Peroxide  |2 NLM 
650 7 |a BBX060AN9V  |2 NLM 
650 7 |a Peroxidases  |2 NLM 
650 7 |a EC 1.11.1.-  |2 NLM 
650 7 |a molybdenum disulfide  |2 NLM 
650 7 |a ZC8B4P503V  |2 NLM 
700 1 |a Wan, Ling  |e verfasserin  |4 aut 
700 1 |a Lv, Suo  |e verfasserin  |4 aut 
700 1 |a Zhu, Dan  |e verfasserin  |4 aut 
700 1 |a Su, Shao  |e verfasserin  |4 aut 
700 1 |a Chao, Jie  |e verfasserin  |4 aut 
700 1 |a Wang, Lianhui  |e verfasserin  |4 aut 
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