Study of Safety and Efficacy of Novel Sirolimus-Eluting Stent Incorporating Properties of Drug Coating Balloon Among Real World Patients Focusing Younger Population (<35 years)

Study of Safety and Efficacy of Novel Sirolimus-Eluting Stent Incorporating Properties of Drug Coating Balloon Among Real World Patients Focusing Younger Population (<35 years)

© 2021 Saudi Heart Association.

Bibliographische Detailangaben
Veröffentlicht in:Journal of the Saudi Heart Association. - 1999. - 33(2021), 4 vom: 18., Seite 321-331
1. Verfasser: Sinha, Santosh Kumar (VerfasserIn)
Weitere Verfasser: Pandey, Umeshwar, Razi, Mahmodullah, Sharma, Awadesh Kumar, Aggarwal, Puneet, Sachan, Mohit, Shukla, Praveen, Thakur, Ramesh
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2021
Zugriff auf das übergeordnete Werk:Journal of the Saudi Heart Association
Schlagworte:Journal Article Drug-eluting stent Patient oriented composite end point Percutaneous coronary intervention Stent thrombosis Target lesion failure
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100 1 |a Sinha, Santosh Kumar  |e verfasserin  |4 aut 
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520 |a OBJECTIVE: Aim of study was to evaluate safety and efficacy of abluminal Mitigator DES + Sirolimus Eluting Stent (Envision Scientific, Surat, India) incorporating novel technology of fusion coating of bioresorbable polymer on both abluminal surface of stent and exposed parts of balloon among real world patients specially focusing younger patients (<35 years) 
520 |a METHOD: 1293 patients received Mitigator DES + at LPS Institute of Cardiology, Kanpur, India. Primary outcome was target lesion failure (TLF)- composite of cardiovascular death, target vessel myocardial infarction (TVMI), and target lesion revascularization (TLR) and secondary end points including peri-procedural device failure (failure of stent delivery, change of stent, stent fracture), target vessel failure (TVF), and patient oriented composite end point (POCE)-composite of all deaths, MI, and revascularization and stent thrombosis (ST) at 1-year follow-up 
520 |a RESULT: Younger population comprised of 374 (29%) patients. Various indications of interventions were STEMI (n = 614; 47.4%), NSTEMI (n = 416; 32.2%), UA (n = 161; 12.5%), and CCS (n = 102; 7.9%). TLF at 1 year in young and overall population were 3.4% and 3.5% respectively which was driven by TVMI and TLR in 1.3% and 1.1% patients respectively. POCE was observed in 9.5% in each group mainly contributed by any revascularization (3.9%). Device failure was significantly lower in young group than overall population (1.3% vs. 2.2%; p = 0.04) which was mainly driven by stent delivery (1.1%) and edge dissection (0.5%). Definite and probable ST was 1.3% and 1.7% respectively which was not significant. Young patients showed insignificantly lower TLF, TVF, ST and POCE and significantly lower device failure (1.3% vs. 2.6%; p = 0.04) when compared to patients >35 years. On multivariate regression analysis, complex lesion, in-stent restenosis, failure of stent delivery and edge dissection were independent predictors of events or device success rate 
520 |a CONCLUSION: Mitigator DES+™ is safe among real world patients, including young population 
650 4 |a Journal Article 
650 4 |a Drug-eluting stent 
650 4 |a Patient oriented composite end point 
650 4 |a Percutaneous coronary intervention 
650 4 |a Stent thrombosis 
650 4 |a Target lesion failure 
700 1 |a Pandey, Umeshwar  |e verfasserin  |4 aut 
700 1 |a Razi, Mahmodullah  |e verfasserin  |4 aut 
700 1 |a Sharma, Awadesh Kumar  |e verfasserin  |4 aut 
700 1 |a Aggarwal, Puneet  |e verfasserin  |4 aut 
700 1 |a Sachan, Mohit  |e verfasserin  |4 aut 
700 1 |a Shukla, Praveen  |e verfasserin  |4 aut 
700 1 |a Thakur, Ramesh  |e verfasserin  |4 aut 
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