Toxicology and carcinogenesis studies of di(2-ethylhexyl) phthalate administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats

This is a work of the US government and distributed under the terms of the Public Domain.

Bibliographische Detailangaben
Veröffentlicht in:	National Toxicology Program technical report series. - 1979. - (2021), 601 vom: 01. Dez.
1. Verfasser:	National Toxicology Program (VerfasserIn)
Weitere Verfasser:	Blystone, C R (BerichterstatterIn), Hubbard, T D (BerichterstatterIn), Elmore, S A (BerichterstatterIn), Blake, J C (BerichterstatterIn), Brown, P (BerichterstatterIn), Burback, B L (BerichterstatterIn), Cesta, M F (BerichterstatterIn), Contos, D A (BerichterstatterIn), Cooper, S D (BerichterstatterIn), Cora, M C (BerichterstatterIn), Crabbs, T A (BerichterstatterIn), Cunny, H C (BerichterstatterIn), Fernando, R A (BerichterstatterIn), Fostel, J M (BerichterstatterIn), Foster, P M (BerichterstatterIn), Gilliam, J (BerichterstatterIn), Gong, H (BerichterstatterIn), Granville, C A (BerichterstatterIn), Gruebbel, M (BerichterstatterIn), Hejtmancik, M R (BerichterstatterIn), Hooth, M J (BerichterstatterIn), King-Herbert, A P (BerichterstatterIn), Lieause, J (BerichterstatterIn), Malarkey, D E (BerichterstatterIn), Martini, C (BerichterstatterIn), McIntyre, B S (BerichterstatterIn), Myers, C (BerichterstatterIn), Parham, F M (BerichterstatterIn), Roberts, G K (BerichterstatterIn), Robinson, V G (BerichterstatterIn), Sayers, N (BerichterstatterIn), Shaw, M (BerichterstatterIn), Shipkowski, K A (BerichterstatterIn), Shockley, K R (BerichterstatterIn), Silinski, M (BerichterstatterIn), South, N L (BerichterstatterIn), Stout, M D (BerichterstatterIn), Travlos, G S (BerichterstatterIn), Vasconcelos, D Y (BerichterstatterIn), Waidyanatha, S (BerichterstatterIn), Walker, N J (BerichterstatterIn), Watson, A T D (BerichterstatterIn), Whittlesey, R (BerichterstatterIn), Willson, G A (BerichterstatterIn), Witt, K L (BerichterstatterIn)
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2021
Zugriff auf das übergeordnete Werk:	National Toxicology Program technical report series
Schlagworte:	Journal Article

Beschreibung
Zusammenfassung:	This is a work of the US government and distributed under the terms of the Public Domain. Di(2-ethylhexyl) phthalate (DEHP) is a member of the phthalate ester chemical class that occurs commonly in the environment and to which humans are widely exposed. Lifetime exposure to DEHP is likely to occur, including during the in utero and early postnatal windows of development. To date, no carcinogenicity assessments of DEHP have used a lifetime exposure paradigm that includes the perinatal period (gestation and lactation). The National Toxicology Program (NTP) tested the hypothesis that exposure during the perinatal period would alter the DEHP carcinogenic response quantitatively (more neoplasms) or qualitatively (different neoplasm types). Two chronic carcinogenicity assessments of DEHP were conducted in which Sprague Dawley (Hsd:Sprague Dawley SD) rats were exposed to dosed feed containing 0, 300, 1,000, 3,000, or 10,000 ppm DEHP for 2 years using different exposure paradigms. In Study 1, groups of 45 F0 time-mated females were provided dosed feed beginning on gestation day (GD) 6 through lactation. On postnatal day (PND) 21, groups of 50 F1 rats per sex continued on the study and were provided dosed feed containing the same DEHP concentration as their respective dam for 2 years. In Study 2, groups of 50 rats per sex, aged 6 to 7 weeks at study start, were provided dosed feed containing DEHP for 2 years. (Abstract Abridged)
Beschreibung:	Date Completed 26.01.2022 Date Revised 24.07.2024 published: Print Citation Status PubMed-not-MEDLINE
ISSN:	0888-8051
DOI:	10.22427/NTP-TR-601