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231225s2022 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202109394
|2 doi
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|a pubmed24n1513.xml
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|a (DE-627)NLM335995756
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|a (NLM)35065000
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Ding, Aixiang
|e verfasserin
|4 aut
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| 245 |
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|a Jammed Micro-Flake Hydrogel for Four-Dimensional Living Cell Bioprinting
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|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 15.04.2022
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|a Date Revised 26.08.2024
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|a published: Print-Electronic
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|a ErratumIn: Adv Mater. 2024 Jan;36(2):e2312067. doi: 10.1002/adma.202312067. - PMID 38102086
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|a Citation Status MEDLINE
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|a © 2022 Wiley-VCH GmbH.
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|a 4D bioprinting is promising to build cell-laden constructs (bioconstructs) with complex geometries and functions for tissue/organ regeneration applications. The development of hydrogel-based 4D bioinks, especially those allowing living cell printing, with easy preparation, defined composition, and controlled physical properties is critically important for 4D bioprinting. Here, a single-component jammed micro-flake hydrogel (MFH) system with heterogeneous size distribution, which differs from the conventional granular microgel, has been developed as a new cell-laden bioink for 4D bioprinting. This jammed cytocompatible MFH features scalable production and straightforward composition with shear-thinning, shear-yielding, and rapid self-healing properties. As such, it can be smoothly printed into stable 3D bioconstructs, which can be further cross-linked to form a gradient in cross-linking density when a photoinitiator and a UV absorber are incorporated. After being subject to shape morphing, a variety of complex bioconstructs with well-defined configurations and high cell viability are obtained. Based on this system, 4D cartilage-like tissue formation is demonstrated as a proof-of-concept. The establishment of this versatile new 4D bioink system may open up a number of applications in tissue engineering
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|a Journal Article
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|a bioinks
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|a cross-linking gradient
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|a four-dimensional printing
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|a shape morphing
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|a tissue engineering
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|a Hydrogels
|2 NLM
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| 700 |
1 |
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|a Jeon, Oju
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cleveland, David
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gasvoda, Kaelyn L
|e verfasserin
|4 aut
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| 700 |
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|a Wells, Derrick
|e verfasserin
|4 aut
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| 700 |
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|a Lee, Sang Jin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Alsberg, Eben
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 34(2022), 15 vom: 31. Apr., Seite e2109394
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|g volume:34
|g year:2022
|g number:15
|g day:31
|g month:04
|g pages:e2109394
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|u http://dx.doi.org/10.1002/adma.202109394
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