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231225s2022 xx |||||o 00| ||eng c |
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|a 10.1007/s10646-021-02512-4
|2 doi
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|a pubmed24n1117.xml
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|a (DE-627)NLM335326587
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|a (NLM)34997370
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
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|a Khoma, Vira
|e verfasserin
|4 aut
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|a Does roundup affect zinc functions in a bivalve mollusk in ex vivo exposure?
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|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 09.03.2022
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|a Date Revised 09.03.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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|a Roundup (Rn), a glyphosate-based formulation, is one of the most commonly used herbicides in the world. It affects non-targeted organisms in several ways, including adhesive activity towards metal ions. Zinc (Zn) plays a crucial role in a number of biochemical processes. In this study, we aim to elucidate the direct impact of Rn on Zn accumulation and Zn-dependent activities in the ex vivo system. To this end, we exposed the samples of the digestive gland of a bivalve mollusk Unio tumidus to 3 µM of Rn (calculated as 3 µM of glyphosate), Zn, Zn chelator (N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine) (TPEN, Tp), and their combinations ZnTp and ZnRn for 17 h. We determined the levels of Zn in the tissue (Zn t) and metallothioneins (Zn-MT), metallothioneins (MTSH), and glutathione (GSH & GSSG), total antioxidant capacity (TAC), lysosomal membrane integrity, and caspase-3 activity. Our study demonstrated that Rn and Tp had different effects on the accumulation and functionality of Zn. Rn did not affect the accumulation of Zn (Zn t, Zn-MT) in the Zn- and ZnRn-groups. On the contrary, Tp produced effects antagonistic to Zn on caspase-3 activity, lysosomal stability, and MTSH concentration. Rn caused particular pro-oxidative effect that decreased GSH level (Rn- and ZnRn-groups) and lysosomal stability (Rn-group). The shared affected index was the GSH/GSSG ratio, which decreased by 2-8 times in each exposure. As the first experience with the application of Tp to indicate Zn activity in mollusks, the study concluded that the ex vivo approach could be useful in the study of numeral aquatic pollutants
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|a Journal Article
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|a Bivalve mollusk
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|a Ex vivo exposure
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|a Metallothioneins
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|a Roundup
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|a TPEN
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|a Zinc
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| 650 |
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|a Water Pollutants, Chemical
|2 NLM
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| 650 |
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7 |
|a Metallothionein
|2 NLM
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| 650 |
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7 |
|a 9038-94-2
|2 NLM
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| 650 |
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|a Zinc
|2 NLM
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| 650 |
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7 |
|a J41CSQ7QDS
|2 NLM
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| 700 |
1 |
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|a Martinyuk, Viktoria
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Matskiv, Tetyana
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yunko, Kateryna
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gnatyshyna, Lesya
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Stoliar, Oksana
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Ecotoxicology (London, England)
|d 1992
|g 31(2022), 2 vom: 07. März, Seite 335-340
|w (DE-627)NLM098212214
|x 1573-3017
|7 nnns
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| 773 |
1 |
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|g volume:31
|g year:2022
|g number:2
|g day:07
|g month:03
|g pages:335-340
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|u http://dx.doi.org/10.1007/s10646-021-02512-4
|3 Volltext
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|d 31
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|h 335-340
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