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231225s2022 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.1c02745
|2 doi
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|a pubmed24n1116.xml
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|a (DE-627)NLM335050379
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|a (NLM)34969246
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Pritzl, Stefanie D
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Optical Membrane Control with Red Light Enabled by Red-Shifted Photolipids
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|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 01.02.2022
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|a Date Revised 01.02.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Photoswitchable phospholipids, or "photolipids", that harbor an azobenzene group in their lipid tails are versatile tools to manipulate and control lipid bilayer properties with light. So far, the limited ultraviolet-A/blue spectral range in which the photoisomerization of regular azobenzene operates has been a major obstacle for biophysical or photopharmaceutical applications. Here, we report on the synthesis of nano- and micrometer-sized liposomes from tetra-ortho-chloro azobenzene-substituted phosphatidylcholine (termed red-azo-PC) that undergoes photoisomerization on irradiation with tissue-penetrating red light (≥630 nm). Photoswitching strongly affects the fluidity and mechanical properties of lipid membranes, although small-angle X-ray scattering and dynamic light scattering measurements reveal only a minor influence on the overall bilayer thickness and area expansion. By controlling the photostationary state and the photoswitching efficiency of red-azo-PC for specific wavelengths, we demonstrate that shape transitions such as budding or pearling and the division of cell-sized vesicles can be achieved. These results emphasize the applicability of red-azo-PC as a nanophotonic tool in synthetic biology and for biomedical applications
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Research Support, U.S. Gov't, Non-P.H.S.
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|a Azo Compounds
|2 NLM
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|a Lipid Bilayers
|2 NLM
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|a Liposomes
|2 NLM
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|a Phosphatidylcholines
|2 NLM
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| 650 |
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|a Phospholipids
|2 NLM
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| 700 |
1 |
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|a Konrad, David B
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ober, Martina F
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Richter, Alexander F
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Frank, James A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Nickel, Bert
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Trauner, Dirk
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lohmüller, Theobald
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 38(2022), 1 vom: 11. Jan., Seite 385-393
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
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|g volume:38
|g year:2022
|g number:1
|g day:11
|g month:01
|g pages:385-393
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|u http://dx.doi.org/10.1021/acs.langmuir.1c02745
|3 Volltext
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|d 38
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|c 01
|h 385-393
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