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231225s2022 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2021.108912
|2 doi
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|a pubmed24n1116.xml
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|a (DE-627)NLM335045375
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|a (NLM)34968746
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|a (PII)S1521-6616(21)00249-7
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Riggenbach, Marguerite M
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Mumps virus-specific immune response outcomes and sex-based differences in a cohort of healthy adolescents
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| 264 |
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1 |
|c 2022
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 25.02.2022
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|a Date Revised 02.01.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2021 Elsevier Inc. All rights reserved.
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|a Despite high levels of MMR-II usage in the US, mumps outbreaks continue to occur. Evidence suggests that mumps vaccine-induced humoral immunity wanes over time. Relatively few studies have examined cell-mediated immunity or reported on sex-based differences. To better understand sex-based differences in the immune response to mumps vaccine, we measured neutralizing antibody titers and mumps-specific cytokine/chemokine responses in a cohort of 748 adolescents and young adults after two doses of MMR vaccine. We observed significantly higher neutralizing antibody titers in females than in males (120.8 IU/mL, 98.7 IU/mL, p = 0.038) but significantly higher secretion levels of MIP-1α, MIP-1β, TNFα, IL-6, IFNγ, and IL-1β in males compared to females. These data demonstrate that sex influences mumps-specific humoral and cell-mediated immune response outcomes, a phenomenon that should be considered during efforts to improve vaccines and prevent future outbreaks
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, N.I.H., Extramural
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| 650 |
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4 |
|a Cellular immunity
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| 650 |
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4 |
|a Chemokine
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| 650 |
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4 |
|a Cytokine
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| 650 |
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4 |
|a MMR vaccine
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| 650 |
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4 |
|a Mumps
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| 650 |
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4 |
|a Sex-based differences
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| 650 |
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7 |
|a Antibodies, Viral
|2 NLM
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| 650 |
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7 |
|a Chemokines
|2 NLM
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| 650 |
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7 |
|a Cytokines
|2 NLM
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| 650 |
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7 |
|a Measles-Mumps-Rubella Vaccine
|2 NLM
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| 700 |
1 |
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|a Haralambieva, Iana H
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ovsyannikova, Inna G
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Schaid, Daniel J
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Poland, Gregory A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kennedy, Richard B
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 234(2022) vom: 07. Jan., Seite 108912
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:234
|g year:2022
|g day:07
|g month:01
|g pages:108912
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| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2021.108912
|3 Volltext
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 234
|j 2022
|b 07
|c 01
|h 108912
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