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231225s2022 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2021.108913
|2 doi
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|a pubmed24n1116.xml
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|a eng
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|a Gaio, Paulo
|e verfasserin
|4 aut
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|a SOCS2 expression in hematopoietic and non-hematopoietic cells during Trypanosoma cruzi infection
|b Correlation with immune response and cardiac dysfunction
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|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 25.02.2022
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|a Date Revised 25.02.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2021 Elsevier Inc. All rights reserved.
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|a Chagas disease has a complex pathogenesis wherein the host immune response is essential for controlling its development. Suppressor of cytokine signaling(SOCS)2 is a crucial protein that regulates cytokine production. In this study, SOCS2 deficiency resulted in an initial imbalance of IL12- and IL-10-producing neutrophils and dendritic cells (DCs), which caused a long-lasting impact reducing inflammatory neutrophils and DCs, and tolerogenic DCs at the peak of acute disease. A reduced number of inflammatory and pro-resolving macrophages, and IL17A-producing CD4+ T cells, and increased lymphocyte apoptosis was found in SOCS2-deficient mice. Electrocardiogram analysis of chimeric mice showed that WT mice that received SOCS2 KO bone marrow transplantation presented increased heart dysfunction. Taken together, the results demonstrated that SOCS2 is a crucial regulator of the immune response during Trypanosoma cruzi infection, and suggest that a SOCS2 genetic polymorphism, or failure of its expression, may increase the susceptibility of cardiomyopathy development in Chagasic patients
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Cardiac function
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|a Chagas disease
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| 650 |
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|a Immunorregulation
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| 650 |
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|a SOCS2
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|a Trypanosoma cruzi
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| 650 |
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|a Socs2 protein, mouse
|2 NLM
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| 650 |
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|a Suppressor of Cytokine Signaling Proteins
|2 NLM
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| 700 |
1 |
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|a Gualdrón-López, Melisa
|e verfasserin
|4 aut
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|a Cramer, Allysson
|e verfasserin
|4 aut
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| 700 |
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|a Esper, Lisia
|e verfasserin
|4 aut
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|a de Menezes Filho, José Evaldo Rodrigues
|e verfasserin
|4 aut
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| 700 |
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|a Cruz, Jader Santos
|e verfasserin
|4 aut
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| 700 |
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|a Teixeira, Mauro Martins
|e verfasserin
|4 aut
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| 700 |
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|a Machado, Fabiana Simão
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 234(2022) vom: 01. Jan., Seite 108913
|w (DE-627)NLM098196855
|x 1521-7035
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|g volume:234
|g year:2022
|g day:01
|g month:01
|g pages:108913
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|u http://dx.doi.org/10.1016/j.clim.2021.108913
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