Treatment of Ruptured and Nonruptured Aneurysms Using a Semisolid Iodinated Embolic Agent

© 2022 Wiley-VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 34(2022), 10 vom: 20. März, Seite e2108266
1. Verfasser: Zhang, Zefu (VerfasserIn)
Weitere Verfasser: Albadawi, Hassan, Fowl, Richard J, Altun, Izzet, Salomao, Marcela A, Jahanyar, Jama, Chong, Brian W, Mayer, Joseph L, Oklu, Rahmi
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2022
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article aneurysm embolization endovascular nanoclay
LEADER 01000caa a22002652 4500
001 NLM334726808
003 DE-627
005 20240929231901.0
007 cr uuu---uuuuu
008 231225s2022 xx |||||o 00| ||eng c
024 7 |a 10.1002/adma.202108266  |2 doi 
028 5 2 |a pubmed24n1552.xml 
035 |a (DE-627)NLM334726808 
035 |a (NLM)34936720 
040 |a DE-627  |b ger  |c DE-627  |e rakwb 
041 |a eng 
100 1 |a Zhang, Zefu  |e verfasserin  |4 aut 
245 1 0 |a Treatment of Ruptured and Nonruptured Aneurysms Using a Semisolid Iodinated Embolic Agent 
264 1 |c 2022 
336 |a Text  |b txt  |2 rdacontent 
337 |a ƒaComputermedien  |b c  |2 rdamedia 
338 |a ƒa Online-Ressource  |b cr  |2 rdacarrier 
500 |a Date Completed 31.03.2022 
500 |a Date Revised 29.09.2024 
500 |a published: Print-Electronic 
500 |a Citation Status MEDLINE 
520 |a © 2022 Wiley-VCH GmbH. 
520 |a Saccular aneurysms (SAs) are focal outpouchings from the lateral wall of an artery. Depending on their morphology and location, minimally invasive treatment options include coil embolization, flow diverter stents, stent-assisted coiling, and liquid embolics. Many drawbacks are associated with these treatment options including recanalization, delayed healing, rebleeding, malpositioning of the embolic or stent, stent stenosis, and even rupture of the SA. To overcome these drawbacks, a nanoclay-based shear-thinning hydrogel (STH) is developed for the endovascular treatment of SAs. Extensive in vitro testing is performed to optimize STH performance, visualization, injectability, and endothelialization in cell culture. Femoral artery saccular aneurysm models in rats and in pigs are created to test stability, efficacy, immune response, endothelialization, and biocompatibility of STH in both ruptured and unruptured SA. Fluoroscopy and computed tomography imaging consistently confirmed SA occlusion without recanalization, migration, or nontarget embolization; STH is also shown to outperform coil embolization of porcine aneurysms. In pigs with catastrophic bleeding due to SA rupture, STH is able to achieve instant hemostasis rescuing the pigs in long-term survival experiments. STH is a promising semisolid iodinated embolic agent that can change the standard of medical practice and potentially save lives 
650 4 |a Journal Article 
650 4 |a aneurysm 
650 4 |a embolization 
650 4 |a endovascular 
650 4 |a nanoclay 
700 1 |a Albadawi, Hassan  |e verfasserin  |4 aut 
700 1 |a Fowl, Richard J  |e verfasserin  |4 aut 
700 1 |a Altun, Izzet  |e verfasserin  |4 aut 
700 1 |a Salomao, Marcela A  |e verfasserin  |4 aut 
700 1 |a Jahanyar, Jama  |e verfasserin  |4 aut 
700 1 |a Chong, Brian W  |e verfasserin  |4 aut 
700 1 |a Mayer, Joseph L  |e verfasserin  |4 aut 
700 1 |a Oklu, Rahmi  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Advanced materials (Deerfield Beach, Fla.)  |d 1998  |g 34(2022), 10 vom: 20. März, Seite e2108266  |w (DE-627)NLM098206397  |x 1521-4095  |7 nnns 
773 1 8 |g volume:34  |g year:2022  |g number:10  |g day:20  |g month:03  |g pages:e2108266 
856 4 0 |u http://dx.doi.org/10.1002/adma.202108266  |3 Volltext 
912 |a GBV_USEFLAG_A 
912 |a SYSFLAG_A 
912 |a GBV_NLM 
912 |a GBV_ILN_350 
951 |a AR 
952 |d 34  |j 2022  |e 10  |b 20  |c 03  |h e2108266