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231225s2022 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202108146
|2 doi
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|a pubmed25n1115.xml
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|a (DE-627)NLM334712130
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|a (NLM)34935224
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
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|a Wen, Kaikai
|e verfasserin
|4 aut
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|a Achieving Efficient NIR-II Type-I Photosensitizers for Photodynamic/Photothermal Therapy upon Regulating Chalcogen Elements
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|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 31.03.2022
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|a Date Revised 01.04.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2022 Wiley-VCH GmbH.
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|a Second near-infrared (NIR-II) window type-I photosensitizers have intrinsic advantages in photodynamic/photothermal therapy (PDT/PTT) of some malignant tumors with deep infiltration, large size, complicated location, and low possibility of surgery/radiotherapy. Herein, three chalcogen-element-based donor-acceptor-type semiconducting polymers (poly[2,2″-((E)-4,4″-bis(2-octyldodecyl)-[6,6″-bithieno[3,2-b]pyrrolylidene]-5,5″(4H,4″H)-dione)-alt-2,5-(thiophene)] (PTS), poly[2,2″-((E)-4,4″-bis(2-octyldodecyl)-[6,6″-bithieno[3,2-b]pyrrolylidene]-5,5″(4H,4″H)-dione)-alt-2,5-(selenophene)] (PTSe), and poly[2,2″-((E)-4,4″-bis(2-octyldodecyl)-[6,6″-bithieno[3,2-b]pyrrolylidene]-5,5″(4H,4'H)-dione)-alt-2,5-(tellurophene)] (PTTe)) are synthesized and fully characterized, demonstrating strong absorption in the NIR-II region. Upon adjusting the chalcogen elements, the intramolecular charge-transfer characteristics and the heavy-atom effect are tuned to enhance the intersystem crossing rate, improving the photodynamic effect. Moreover, the energy levels and Gibbs free energies are tuned to facilitate the type-I photodynamic process. As a result, PTTe nanoparticles (NPs) produce superoxide anion radicals (O2 •- ) more efficiently and demonstrate higher photothermal conversion efficiency than PTS and PTSe NPs upon NIR-II (1064 nm) laser irradiation, exhibiting unprecedented NIR-II type-I PDT/PTT performance in vitro and in vivo. This work provides ideas for achieving high-performance NIR-II type-I PDT/PTT semiconducting polymers for hypoxic oncotherapy
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|a Journal Article
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|a chalcogen elements
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|a photodynamic/photothermal therapy
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|a second near-infrared region
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|a semiconducting polymers
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|a type-I photosensitizers
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|a Chalcogens
|2 NLM
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| 650 |
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|a Photosensitizing Agents
|2 NLM
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| 700 |
1 |
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|a Tan, Hui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Peng, Qian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Hao
|e verfasserin
|4 aut
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1 |
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|a Ma, Han
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Lu
|e verfasserin
|4 aut
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1 |
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|a Peng, Aidong
|e verfasserin
|4 aut
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1 |
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|a Shi, Qinqin
|e verfasserin
|4 aut
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|a Cai, Xiaodong
|e verfasserin
|4 aut
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| 700 |
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|a Huang, Hui
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 34(2022), 7 vom: 07. Feb., Seite e2108146
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
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| 773 |
1 |
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|g volume:34
|g year:2022
|g number:7
|g day:07
|g month:02
|g pages:e2108146
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|u http://dx.doi.org/10.1002/adma.202108146
|3 Volltext
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