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231225s2021 xx |||||o 00| ||eng c |
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|a 10.3928/23258160-20211124-01
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|a eng
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1 |
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|a Chen, Po-Yu Jay
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Aflibercept for Retinopathy of Prematurity
|b A Systematic Review and Meta-Analysis
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|c 2021
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|a Text
|b txt
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 08.04.2022
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|a Date Revised 08.04.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a BACKGROUND AND OBJECTIVE: To determine the effectiveness of aflibercept in retinopathy of prematurity (ROP)
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|a PATIENTS AND METHODS: We performed a systematic review and meta-analysis of proportions from the literature in PubMed and Cochrane Library using search terms related to the use of aflibercept in ROP. Studies in non-preterm infants or that did not use aflibercept as the initial treatment were excluded. Risk of bias was assessed by the ROBINS-I (Risk Of Bias in Non-randomized Studies of Interventions) tool
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|a RESULTS: We identified six case series. Collectively, 218 eyes were treated with aflibercept for ROP. We found an average 97% (95% confidence interval [CI], 93% to 99%) regression rate with aflibercept and an average 16% (95% CI, 5% to 41%) recurrence rate. With the exception of one outlier study, these numbers are similar to previous reports using anti-vascular endothelial growth factor (VEGF) agents in ROP
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|a CONCLUSIONS: Aflibercept holds promise for use in ROP and has been demonstrated to be efficacious in six case series. Randomized, controlled clinical trials appear warranted to compare aflibercept with other anti-VEGF agents. [Ophthalmic Surg Lasers Imaging. 2021;52:673-681.]
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|a Journal Article
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|a Systematic Review
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|a Angiogenesis Inhibitors
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|a Recombinant Fusion Proteins
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|a Rossin, Elizabeth J
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|a Vavvas, Demetrios G
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Ophthalmic surgery, lasers & imaging retina
|d 2013
|g 52(2021), 12 vom: 22. Dez., Seite 673-681
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