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231225s2022 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202108325
|2 doi
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|a pubmed24n1114.xml
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|a eng
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| 100 |
1 |
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|a Wang, Juan
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Endogenous Electric-Field-Coupled Electrospun Short Fiber via Collecting Wound Exudation
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|c 2022
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|a Text
|b txt
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 31.03.2022
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|a Date Revised 01.04.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2022 Wiley-VCH GmbH.
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|a Endogenous electric fields (EF) are the basis of bioelectric signal conduction and the priority signal for damaged tissue regeneration. Tissue exudation directly affects the characteristics of endogenous EF. However, current biomaterials lead to passive repair of defect tissue due to limited management of early wound exudates and inability to actively respond to coupled endogenous EF. Herein, the 3D bionic short-fiber scaffold with the functions of early biofluid collection, response to coupled endogenous EF, is constructed by guiding the short fibers into a 3D network structure and subsequent multifunctional modification. The scaffold exhibits rapid reversible water absorption, reaching maximum after only 30 s. The stable and uniform distribution of polydopamine-reduced graphene oxide endows the scaffold with stable electrical and mechanical performances even after long-term immersion. Due to its unique - bionic structure and tissue affinity, the scaffold further acts as an "electronic skin," which transmits endogenous bioelectricity via absorbing wound exudates, promoting the treatment of diabetic wounds. Furthermore, under the endogenous EF, the cascade release of vascular endothelial growth factor accelerates the healing process. Thus, the versatile scaffold is expected to be an ideal candidate for repairing different defect tissues, especially electrosensitive tissues
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|a Journal Article
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|a 3D short fiber scaffold
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4 |
|a cascade reaction
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4 |
|a endogenous electric fields
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4 |
|a exudation
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4 |
|a wound healing
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|a Biocompatible Materials
|2 NLM
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| 650 |
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|a Vascular Endothelial Growth Factor A
|2 NLM
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| 700 |
1 |
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|a Lin, Jiawei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Liang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Deng, Lianfu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cui, Wenguo
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 34(2022), 9 vom: 16. März, Seite e2108325
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|x 1521-4095
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|g volume:34
|g year:2022
|g number:9
|g day:16
|g month:03
|g pages:e2108325
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|u http://dx.doi.org/10.1002/adma.202108325
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