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231225s2022 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202107892
|2 doi
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|a pubmed25n1114.xml
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|a (DE-627)NLM33426619X
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|a (NLM)34890082
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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1 |
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|a Kilic, Tugba
|e verfasserin
|4 aut
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|a Zwitterionic Polymer Electroplating Facilitates the Preparation of Electrode Surfaces for Biosensing
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|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 02.03.2022
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|a Date Revised 24.08.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2022 Wiley-VCH GmbH.
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|a Surface chemistry critically affects the diagnostic performance of biosensors. An ideal sensor surface should be resistant to nonspecific protein adsorption, yet be conducive to analytical responses. Here a new polymeric material, zwitterionic polypyrrole (ZiPPy), is reported to produce optimal surface condition for biosensing electrodes. ZiPPy combines two unique advantages: the zwitterionic function that efficiently hydrates electrode surface, hindering nonspecific binding of hydrophobic proteins; and the pyrrole backbone, which enables rapid (<7 min), controlled deposition of ZiPPy through electropolymerization. ZiPPy-coated electrodes show lower electrochemical impedance and less nonspecific protein adsorption (low fouling), outperforming bare and polypyrrole-coated electrodes. Moreover, affinity ligands for target biomarkers can be immobilized together with ZiPPy in a single-step electropolymerization. ZiPPy-coated electrodes are developed with specificity for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The prepared sensor detects SARS-CoV-2 antibodies in human saliva down to 50 ng mL-1 , without the need for sample purification or secondary labeling
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|a Journal Article
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|a SARS-CoV-2
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|a electrochemical impedance spectroscopy
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4 |
|a electropolymerization
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|a saliva analysis
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|a zwitterionic polymers
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|a Antibodies, Viral
|2 NLM
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|a Polymers
|2 NLM
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7 |
|a Pyrroles
|2 NLM
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7 |
|a polypyrrole
|2 NLM
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| 650 |
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7 |
|a 30604-81-0
|2 NLM
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| 650 |
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7 |
|a Gold
|2 NLM
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| 650 |
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7 |
|a 7440-57-5
|2 NLM
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| 700 |
1 |
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|a Gessner, Isabel
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cho, Young Kwan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jeong, Naebong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Quintana, Jeremy
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Weissleder, Ralph
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lee, Hakho
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 34(2022), 8 vom: 01. Feb., Seite e2107892
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
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| 773 |
1 |
8 |
|g volume:34
|g year:2022
|g number:8
|g day:01
|g month:02
|g pages:e2107892
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|u http://dx.doi.org/10.1002/adma.202107892
|3 Volltext
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