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231225s2022 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202106607
|2 doi
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|a pubmed24n1113.xml
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|a (DE-627)NLM334029856
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|a (NLM)34866253
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Alt, Karen
|e verfasserin
|4 aut
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|a Self-Assembly of Oriented Antibody-Decorated Metal-Organic Framework Nanocrystals for Active-Targeting Applications
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|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 27.05.2022
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|a Date Revised 27.05.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2021 The Authors. Advanced Materials published by Wiley-VCH GmbH.
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|a Antibody (Ab)-targeted nanoparticles are becoming increasingly important for precision medicine. By controlling the Ab orientation, targeting properties can be enhanced; however, to afford such an ordered configuration, cumbersome chemical functionalization protocols are usually required. This aspect limits the progress of Abs-nanoparticles toward nanomedicine translation. Herein, a novel one-step synthesis of oriented monoclonal Ab-decorated metal-organic framework (MOF) nanocrystals is presented. The crystallization of a zinc-based MOF, Zn2 (mIM)2 (CO3 ), from a solution of Zn2+ and 2-methylimidazole (mIM), is triggered by the fragment crystallizable (Fc) region of the Ab. This selective growth yields biocomposites with oriented Abs on the MOF nanocrystals (MOF*Ab): the Fc regions are partially inserted within the MOF surface and the antibody-binding regions protrude from the MOF surface toward the target. This ordered configuration imparts antibody-antigen recognition properties to the biocomposite and shows preserved target binding when compared to the parental antibodies. Next, the biosensing performance of the system is tested by loading MOF*Ab with luminescent quantum dots (QD). The targeting efficiency of the QD-containing MOF*Ab is again, fully preserved. The present work represents a simple self-assembly approach for the fabrication of antibody-decorated MOF nanocrystals with broad potential for sensing, diagnostic imaging, and targeted drug delivery
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|a Journal Article
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|a antibodies
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|a crystallization
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|a metal-organic frameworks
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|a self-assembly
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|a targeting
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|a Antibodies
|2 NLM
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|a Metal-Organic Frameworks
|2 NLM
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|a Carraro, Francesco
|e verfasserin
|4 aut
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|a Jap, Edwina
|e verfasserin
|4 aut
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1 |
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|a Linares-Moreau, Mercedes
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Riccò, Raffaele
|e verfasserin
|4 aut
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| 700 |
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|a Righetto, Marcello
|e verfasserin
|4 aut
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| 700 |
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|a Bogar, Marco
|e verfasserin
|4 aut
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| 700 |
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|a Amenitsch, Heinz
|e verfasserin
|4 aut
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|a Hashad, Rania A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Doonan, Christian
|e verfasserin
|4 aut
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| 700 |
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|a Hagemeyer, Christoph E
|e verfasserin
|4 aut
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|a Falcaro, Paolo
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 34(2022), 21 vom: 05. Mai, Seite e2106607
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
1 |
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|g volume:34
|g year:2022
|g number:21
|g day:05
|g month:05
|g pages:e2106607
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|u http://dx.doi.org/10.1002/adma.202106607
|3 Volltext
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