Squarate Cross-Linked Gelatin Hydrogels as Three-Dimensional Scaffolds for Biomedical Applications

Hydrogels are useful platforms as three-dimensional (3D) scaffolds for cell culture, drug-release systems, and regenerative medicine applications. Here, we propose a novel chemical cross-linking approach by the use of 3,4-diethoxy-3-cyclobutene-1,2-dione or diethyl squarate for the preparation of 5...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 37(2021), 48 vom: 07. Dez., Seite 14050-14058
1. Verfasser: Stucchi, Simone (VerfasserIn)
Weitere Verfasser: Colombo, Danilo, Guizzardi, Roberto, D'Aloia, Alessia, Collini, Maddalena, Bouzin, Margaux, Costa, Barbara, Ceriani, Michela, Natalello, Antonino, Pallavicini, Piersandro, Cipolla, Laura
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2021
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Hydrogels Gelatin 9000-70-8
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520 |a Hydrogels are useful platforms as three-dimensional (3D) scaffolds for cell culture, drug-release systems, and regenerative medicine applications. Here, we propose a novel chemical cross-linking approach by the use of 3,4-diethoxy-3-cyclobutene-1,2-dione or diethyl squarate for the preparation of 5 and 10% w/v gelatin-based hydrogels. Hydrogels showed good swelling properties, and the 5% gelatin-based hydrogel proved suitable as a 3D cell culture scaffold for the chondrocyte cell line C28/I2. In addition, diffusion properties of different sized molecules inside the hydrogel were determined 
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700 1 |a Colombo, Danilo  |e verfasserin  |4 aut 
700 1 |a Guizzardi, Roberto  |e verfasserin  |4 aut 
700 1 |a D'Aloia, Alessia  |e verfasserin  |4 aut 
700 1 |a Collini, Maddalena  |e verfasserin  |4 aut 
700 1 |a Bouzin, Margaux  |e verfasserin  |4 aut 
700 1 |a Costa, Barbara  |e verfasserin  |4 aut 
700 1 |a Ceriani, Michela  |e verfasserin  |4 aut 
700 1 |a Natalello, Antonino  |e verfasserin  |4 aut 
700 1 |a Pallavicini, Piersandro  |e verfasserin  |4 aut 
700 1 |a Cipolla, Laura  |e verfasserin  |4 aut 
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